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Difference Between Provision for Income Taxes and Amounts Computed by Applying Federal Statutory Income Tax Rate to Loss before Taxes (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Income Tax Disclosure [Abstract]
Federal statutory tax	$ (19,277)	$ (21,329)	$ (20,243)
Tax Act revaluation of deferred taxes	81,923
Tax Act deemed income inclusion	1,083
Federal research credits	(1,000)	(809)	(838)
Warrants			(3,565)
Expiration of federal loss carryovers			3,337
Expiration of California loss carryovers	1,475
Change in valuation allowance	(59,462)	3,940	11,754
Non-deductible stock based compensation	1,382	484	449
Change in state apportionment			4,085
Revision to prior year items		17,200
Other	(2,237)	689	1,350
Provision (benefit) for income taxes	$ 3,887	$ 175	$ (3,671)

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