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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Operating activities      
Net loss $ (60,585,000) $ (62,906,000) $ (55,868,000)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation and amortization 1,811,000 1,817,000 1,699,000
Stock-based compensation 9,355,000 8,065,000 6,730,000
Changes in valuation of warrant liability     (3,566,000)
Non-cash interest expense 551,000 1,017,000 508,000
Non-cash deferred manufacturing and development expense     434,000
Deferred income taxes (119,000) 28,000 7,000
Impairment of long-lived assets 0 150,000 0
Non-cash tax expense (benefit) from other unrealized gain on available-for-sale securities 3,825,000   (3,825,000)
Gain on sale of investment in marketable equity securities (3,466,000) (750,000)  
Changes in operating assets and liabilities:      
Accounts receivable (5,547,000) (1,074,000) (301,000)
Inventories (2,092,000) (1,781,000) 3,991,000
Other assets 1,107,000 1,327,000 1,379,000
Accounts payable 2,487,000 3,261,000 (3,866,000)
Accrued liabilities and other non-current liabilities (507,000) 1,330,000 1,359,000
Manufacturing and development obligations 680,000 (3,568,000)  
Deferred product revenue 265,000 (445,000) 190,000
Net cash used in operating activities (52,235,000) (53,529,000) (51,129,000)
Investing activities      
Capital expenditures (353,000) (563,000) (722,000)
Purchases of investments (68,792,000) (82,811,000) (90,407,000)
Proceeds from maturities and sale of investments 69,566,000 63,450,000 92,645,000
Net cash provided by (used in) investing activities 421,000 (19,924,000) 1,516,000
Financing activities      
Net proceeds from equity incentives and warrants 2,428,000 3,068,000 12,767,000
Net proceeds from public offering 30,197,000 22,121,000 75,300,000
Proceeds from loans 30,000,000   10,000,000
Repayment of debt (19,625,000) (622,000) (113,000)
Net cash provided by financing activities 43,000,000 24,567,000 97,954,000
Net (decrease) increase in cash, cash equivalents and restricted cash (8,814,000) (48,886,000) 48,341,000
Cash, cash equivalents and restricted cash, beginning of year 22,744,000 71,630,000 23,289,000
Cash, cash equivalents and restricted cash, end of year 13,930,000 22,744,000 71,630,000
Supplemental disclosures:      
Cash paid for interest 2,034,000 1,366,000 1,087,000
Cash paid for income taxes $ 160,000 $ 157,000 153,000
Unpaid manufacturing and development obligation     $ 7,051,000