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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2018 | Jun. 30, 2017
Operating activities |  |
Net loss | $ (27,167) | $ (35,681)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 788 | 904
Stock-based compensation | 4,908 | 4,617
Non-cash interest expense | 537 | 285
Loss on disposal of property and equipment | 5 |
Deferred income taxes | 1 | 12
Non-cash tax expense from other unrealized loss on available-for-sale securities |  | 3,825
Gain on sale of investment in marketable equity securities |  | (3,466)
Changes in operating assets and liabilities: |  |
Accounts receivable | 1,027 | (1,064)
Inventories | 1,458 | 237
Other assets | (1,587) | 704
Accounts payable | 154 | 1,085
Accrued liabilities and other non-current liabilities | 553 | (1,457)
Manufacturing and development obligations | (148) | 419
Deferred product revenue | 216 | 233
Net cash used in operating activities | (19,255) | (29,347)
Investing activities |  |
Capital expenditures | (145) | (353)
Purchases of investments | (75,462) | (20,749)
Proceeds from maturities and sale of investments | 24,002 | 38,465
Net cash (used in) provided by investing activities | (51,605) | 17,363
Financing activities |  |
Net proceeds from equity incentives | 4,912 | 2,052
Net proceeds from public offering | 69,117 | 9,644
Repayment of debt | (65) | (1,930)
Net cash provided by financing activities | 73,964 | 9,766
Net increase (decrease) in cash, cash equivalents and restricted cash | 3,104 | (2,218)
Cash, cash equivalents and restricted cash, beginning of period | 13,930 | 22,744
Cash, cash equivalents and restricted cash, end of period | $ 17,034 | $ 20,526

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