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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Operating activities    
Net loss $ (27,167) $ (35,681)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 788 904
Stock-based compensation 4,908 4,617
Non-cash interest expense 537 285
Loss on disposal of property and equipment 5  
Deferred income taxes 1 12
Non-cash tax expense from other unrealized loss on available-for-sale securities   3,825
Gain on sale of investment in marketable equity securities   (3,466)
Changes in operating assets and liabilities:    
Accounts receivable 1,027 (1,064)
Inventories 1,458 237
Other assets (1,587) 704
Accounts payable 154 1,085
Accrued liabilities and other non-current liabilities 553 (1,457)
Manufacturing and development obligations (148) 419
Deferred product revenue 216 233
Net cash used in operating activities (19,255) (29,347)
Investing activities    
Capital expenditures (145) (353)
Purchases of investments (75,462) (20,749)
Proceeds from maturities and sale of investments 24,002 38,465
Net cash (used in) provided by investing activities (51,605) 17,363
Financing activities    
Net proceeds from equity incentives 4,912 2,052
Net proceeds from public offering 69,117 9,644
Repayment of debt (65) (1,930)
Net cash provided by financing activities 73,964 9,766
Net increase (decrease) in cash, cash equivalents and restricted cash 3,104 (2,218)
Cash, cash equivalents and restricted cash, beginning of period 13,930 22,744
Cash, cash equivalents and restricted cash, end of period $ 17,034 $ 20,526