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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2018 | Sep. 30, 2017
Operating activities |  |
Net loss | $ (41,359) | $ (49,099)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 1,109 | 1,359
Stock-based compensation | 7,579 | 7,008
Non-cash interest expense | 892 | 282
Loss on disposal of property and equipment | 5 |
Deferred income taxes | 2 | 19
Non-cash tax expense from other realized gain on available-for-sale securities |  | 3,825
Gain on sale of investment in marketable equity securities |  | (3,466)
Changes in operating assets and liabilities: |  |
Accounts receivable | 1,939 | (3,608)
Inventories | 1,043 | (1,800)
Other assets | (2,724) | (379)
Accounts payable | 3,020 | 4,022
Accrued liabilities and other non-current liabilities | 4,457 | (1,477)
Manufacturing and development obligations | (187) | 600
Deferred product revenue | 73 | 514
Net cash used in operating activities | (24,151) | (42,200)
Investing activities |  |
Capital expenditures | (624) | (354)
Purchases of investments | (80,453) | (50,183)
Proceeds from maturities and sale of investments | 30,002 | 55,566
Net cash (used in) provided by investing activities | (51,075) | 5,029
Financing activities |  |
Net proceeds from equity incentives | 7,150 | 2,421
Net proceeds from public offering | 79,301 | 18,840
Proceeds from loans |  | 30,000
Repayment of debt | (99) | (19,593)
Net cash provided by financing activities | 86,352 | 31,668
Net increase (decrease) in cash, cash equivalents and restricted cash | 11,126 | (5,503)
Cash, cash equivalents and restricted cash, beginning of period | 13,930 | 22,744
Cash, cash equivalents and restricted cash, end of period | $ 25,056 | $ 17,241

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