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Summary of Significant Accounting Policies (Tables) | 9 Months Ended
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Sep. 30, 2018
Accounting Policies [Abstract] |
Summary of Product Revenue by Geographical Locations of Customers | Product revenue by geographical locations of customers during the three and nine months ended September 30, 2018 and 2017, were as follows (in thousands):
|  | Three Months Ended |  |  | Nine Months Ended |
|  | September 30, |  |  | September 30, |
|  | 2018 |  |  | 2017 |  |  | 2018 |  |  | 2017 |
Product revenue: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Europe, Middle East and Africa |  | $ | 11,866 |  |  | $ | 9,045 |  |  | $ | 34,890 |  |  | $ | 22,793 |
North America |  |  | 3,117 |  |  |  | 1,524 |  |  |  | 8,653 |  |  |  | 3,872 |
Other |  |  | 416 |  |  |  | 228 |  |  |  | 840 |  |  |  | 663 |
Total product revenue |  | $ | 15,399 |  |  | $ | 10,797 |  |  | $ | 44,383 |  |  | $ | 27,328 |
Anti-Dilutive Effect of Common Shares | The table below presents potential shares that were excluded from the calculation of the weighted average number of shares outstanding used for the calculation of diluted net loss per share. These are excluded from the calculation due to their anti-dilutive effect for the three and nine months ended September 30, 2018 and 2017 (shares in thousands):
|  | Three Months Ended |  |  | Nine Months Ended |
|  | September 30, |  |  | September 30, |
|  | 2018 |  |  | 2017 |  |  | 2018 |  |  | 2017 |
Weighted average number of anti-dilutive potential shares: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock options |  |  | 17,882 |  |  |  | 17,629 |  |  |  | 18,137 |  |  |  | 17,424 |
Restricted stock units |  |  | 1,989 |  |  |  | 1,313 |  |  |  | 1,865 |  |  |  | 1,211 |
Employee stock purchase plan rights |  |  | 3 |  |  |  | — |  |  |  | 2 |  |  |  | 11 |
Total |  |  | 19,874 |  |  |  | 18,942 |  |  |  | 20,004 |  |  |  | 18,646 |

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- Definition Tabular disclosure of disaggregation of revenue into categories depicting how nature, amount, timing, and uncertainty of revenue and cash flows are affected by economic factor. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=109196051&loc=SL49130545-203045 + Details
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- Definition Tabular disclosure of securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) in the future that were not included in the computation of diluted EPS because to do so would increase EPS amounts or decrease loss per share amounts for the period presented, by antidilutive securities. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 260 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=6371337&loc=d3e3550-109257 + Details
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