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Stock-Based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2018
Information Regarding Stock Options Outstanding Stock Options Vested and Expected to Vest and Stock Options Exercisable | Information regarding the Company’s stock options outstanding, stock options vested and expected to vest, and stock options exercisable at December 31, 2018, was as follows (in thousands except weighted average exercise price and contractual term):
|  | Number of Shares |  |  | Weighted Average Exercise Price |  |  | Weighted Average Remaining Contractual Term (Years) |  |  | Aggregate Intrinsic Value |
Balances at December 31, 2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock options outstanding |  |  | 17,560 |  |  | $ | 4.47 |  |  |  | 6.3 |  |  | $ | 14,345 |
Stock options vested and expected to vest |  |  | 17,276 |  |  |  | 4.47 |  |  |  | 6.3 |  |  |  | 14,179 |
Stock options exercisable |  |  | 12,336 |  |  |  | 4.37 |  |  |  | 5.4 |  |  |  | 11,402 |
Recognition of Stock-Based Compensation Expense | Stock-based compensation expense recognized on the Company’s consolidated statements of operations for the years ended December 31, 2018, 2017 and 2016, was as follows (in thousands):
|  | Year Ended December 31, |
|  | 2018 |  |  | 2017 |  |  | 2016 |
Research and development |  | $ | 1,669 |  |  | $ | 1,323 |  |  | $ | 1,091 |
Selling, general and administrative |  |  | 8,725 |  |  |  | 8,032 |  |  |  | 6,974 |
Total stock-based compensation expense |  | $ | 10,394 |  |  | $ | 9,355 |  |  | $ | 8,065 |
Weighted Average Assumptions Used to Value Stock-Based Awards | The weighted average assumptions used to value the Company’s stock-based awards for the years ended December 31, 2018, 2017 and 2016, was as follows:
|  | Year Ended December 31, |
|  | 2018 |  |  | 2017 |  |  | 2016 |
Stock Options: |  |  |  |  |  |  |  |  |  |  |  |
Expected term (in years) |  |  | 6.07 |  |  |  | 6.12 |  |  |  | 5.85 |
Estimated volatility |  | 50% |  |  | 47% |  |  | 49% |
Risk-free interest rate |  | 2.72% |  |  | 2.14% |  |  | 1.41% |
Expected dividend yield |  | 0% |  |  | 0% |  |  | 0% |
Employee Stock Purchase Plan Rights: |  |  |  |  |  |  |  |  |  |  |  |
Expected term (in years) |  |  | 0.74 |  |  |  | 0.92 |  |  |  | 0.76 |
Estimated volatility |  | 47% |  |  | 57% |  |  | 47% |
Risk-free interest rate |  | 2.34% |  |  | 1.08% |  |  | 0.55% |
Expected dividend yield |  | 0% |  |  | 0% |  |  | 0% |
2008 Equity Incentive Plan |
Activity Under Equity Incentive Plans Related to Stock Options | Activity under the Company’s equity incentive plans related to stock options is set forth below (in thousands except per share amounts):
|  | Number of Options Outstanding |  |  | Weighted Average Exercise Price per Share |
Balances at December 31, 2017 |  |  | 17,138 |  |  | $ | 4.27 |
Granted |  |  | 3,447 |  |  |  | 4.78 |
Exercised |  |  | (2,195 | ) |  |  | 3.19 |
Forfeited |  |  | (678 | ) |  |  | 4.73 |
Expired |  |  | (152 | ) |  |  | 5.93 |
Balances at December 31, 2018 |  |  | 17,560 |  |  |  | 4.47 |
Activity Under Equity Incentive Plans Related to RSUs | Activity under the Company’s equity incentive plans related to RSUs is set forth below (in thousands except per share amounts):
|  | Number of Shares Outstanding |  |  | Weighted Average Grant Date Fair Value per Share |
Balances at December 31, 2017 |  |  | 1,256 |  |  | $ | 4.53 |
Granted (1) |  |  | 1,420 |  |  |  | 4.51 |
Vested |  |  | (521 | ) |  |  | 4.45 |
Forfeited |  |  | (154 | ) |  |  | 4.22 |
Balances at December 31, 2018 |  |  | 2,001 |  |  |  | 4.56 |
| (1) | Includes the number of shares issuable under the performance-based restricted stock unit awards granted during the twelve months ended December 31, 2018.

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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=115993241&loc=d3e301413-122809 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5047-113901 + Details
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- Definition Tabular disclosure of the number and weighted-average grant date fair value for restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock units that were granted, vested, or forfeited during the year. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901 + Details
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