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Significant Components of Deferred Tax Assets and Liabilities (Detail) - USD ($) $ in Thousands | Dec. 31, 2018 | Dec. 31, 2017
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 125,016 | $ 117,028
Research and development credit carryforwards | 26,705 | 25,061
Capitalized research and development | 15,293 | 17,195
Compensation related items | 8,310 | 7,011
Other | 4,013 | 3,116
Total deferred tax assets | 179,337 | 169,411
Valuation allowance | (179,245) | (169,332)
Net deferred tax assets | 92 | 79
Deferred tax liabilities: |  |
Amortization of goodwill | 127 | 111
Total deferred tax liabilities | $ 127 | $ 111

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