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Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2018

Accounting Policies [Abstract]

Summary of Product Revenue by Geographical Locations of Customers

Product revenue by geographical locations of customers during the years ended December 31, 2018, 2017 and 2016, were as follows (in thousands):

		Year Ended December 31,
		2018				2017				2016
Product revenue:
Europe, Middle East and Africa		$	46,974			$	36,241			$	30,716
North America			12,696				6,325				4,569
Other			1,238				1,002				1,898
Total product revenue		$	60,908			$	43,568			$	37,183

Computation of Basic and Diluted Net Loss per Share

The following table sets forth the reconciliation of the numerator and denominator used in the computation of basic and diluted net loss per share for the years ended December 31, 2018, 2017 and 2016 (in thousands, except per share amounts):

		Year Ended December 31,
		2018				2017				2016
Numerator for Basic and Diluted:
Net loss used for basic calculation		$	(57,564	)		$	(60,585	)		$	(62,906	)
Denominator:
Basic weighted average number of shares outstanding			131,663				108,221				101,826
Effect of dilutive potential shares			—				—				—
Diluted weighted average number of shares outstanding			131,663				108,221				101,826
Net loss per share:
Basic		$	(0.44	)		$	(0.56	)		$	(0.62	)
Diluted			(0.44	)			(0.56	)			(0.62	)

Anti-Dilutive Effect of Common Shares

The table below presents potential shares that were excluded from the calculation of the weighted average number of shares outstanding used for the calculation of diluted net loss per share. These are excluded from the calculation due to their anti-dilutive effect for the years ended December 31, 2018, 2017 and 2016 (shares in thousands):

		Year Ended December 31,
		2018				2017				2016
Weighted average number of anti-dilutive potential shares:
Stock options			18,031				17,373				15,592
Restricted stock units			1,902				1,225				576
Employee stock purchase plan rights			20				21				43
Total			19,953				18,619				16,211

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Tabular disclosure of disaggregation of revenue into categories depicting how nature, amount, timing, and uncertainty of revenue and cash flows are affected by economic factor.

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
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Tabular disclosure of securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) in the future that were not included in the computation of diluted EPS because to do so would increase EPS amounts or decrease loss per share amounts for the period presented, by antidilutive securities.

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Tabular disclosure of an entity's basic and diluted earnings per share calculations, including a reconciliation of numerators and denominators of the basic and diluted per-share computations for income from continuing operations.

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