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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Operating activities      
Net loss $ (57,564,000) $ (60,585,000) $ (62,906,000)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation and amortization 1,445,000 1,811,000 1,817,000
Stock-based compensation 10,394,000 9,355,000 8,065,000
Non-cash interest expense 1,248,000 551,000 1,017,000
Loss on disposal of property and equipment 5,000    
Deferred income taxes 4,000 (119,000) 28,000
Impairment of long-lived assets 0 0 150,000
Non-cash tax expense from realized gain on available-for-sale securities   3,825,000  
Gain on sale of investment in marketable equity securities   (3,466,000) (750,000)
Changes in operating assets and liabilities:      
Accounts receivable 3,663,000 (5,547,000) (1,074,000)
Inventories 806,000 (2,092,000) (1,781,000)
Other assets (2,744,000) 1,107,000 1,327,000
Accounts payable 5,683,000 2,487,000 3,261,000
Accrued liabilities and other non-current liabilities 6,042,000 (507,000) 1,330,000
Manufacturing and development obligations (266,000) 680,000 (3,568,000)
Deferred product revenue 38,000 265,000 (445,000)
Net cash used in operating activities (31,246,000) (52,235,000) (53,529,000)
Investing activities      
Capital expenditures (1,144,000) (353,000) (563,000)
Purchases of investments (80,701,000) (68,792,000) (82,811,000)
Proceeds from maturities and sale of investments 37,997,000 69,566,000 63,450,000
Net cash (used in) provided by investing activities (43,848,000) 421,000 (19,924,000)
Financing activities      
Net proceeds from equity incentives 7,848,000 2,428,000 3,068,000
Net proceeds from public offering 85,036,000 30,197,000 22,121,000
Proceeds from loans   30,000,000  
Repayment of debt (133,000) (19,625,000) (622,000)
Net cash provided by financing activities 92,751,000 43,000,000 24,567,000
Net increase (decrease) in cash, cash equivalents and restricted cash 17,657,000 (8,814,000) (48,886,000)
Cash, cash equivalents and restricted cash, beginning of year 13,930,000 22,744,000 71,630,000
Cash, cash equivalents and restricted cash, end of year 31,587,000 13,930,000 22,744,000
Supplemental disclosure of cash flow information:      
Cash paid for interest 2,728,000 2,034,000 1,366,000
Cash paid for income taxes 254,000 $ 160,000 $ 157,000
Non-cash investing activities:      
Non-cash purchases of capital expenditures $ 2,222,000