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Difference Between Provision for Income Taxes and Amounts Computed by Applying Federal Statutory Income Tax Rate to Loss before Taxes (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Income Tax Disclosure [Abstract]
Federal statutory tax	$ (12,040)	$ (19,277)	$ (21,329)
Tax Act revaluation of deferred taxes		81,923
Tax Act deemed income inclusion		1,083
Federal research credits	(1,390)	(1,000)	(809)
State research credits	655	628	449
Expiration of federal carryovers	4,154
Expiration of state carryovers	1,344	1,475	1,193
Change in valuation allowance	9,913	(59,462)	3,940
Compensation related items	(361)	1,382	484
State taxes	(1,141)	(803)	(990)
Revision to prior year items			17,200
Other	405	(806)	935
Provision for income taxes	$ 229	$ 3,887	$ 175

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