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Gross Amounts and Dates of Expiration of Tax Credits and Carryovers (Detail) - USD ($) $ in Thousands	Dec. 31, 2018	Dec. 31, 2017
Income Tax Disclosure [Line Items]
Federal losses carryovers	$ 571,992
California loss carryovers	59,752
Research credits	26,705	$ 25,061
Federal foreign tax credits	610
Federal
Income Tax Disclosure [Line Items]
Research credits	18,631
California
Income Tax Disclosure [Line Items]
Research credits	10,220
Expires 2019-2021
Income Tax Disclosure [Line Items]
Federal losses carryovers	66,880
Expires 2019-2021 | Federal
Income Tax Disclosure [Line Items]
Research credits	5,269
Expires 2022-2028
Income Tax Disclosure [Line Items]
Federal losses carryovers	171,270
Federal foreign tax credits	610
Expires 2022-2028 | Federal
Income Tax Disclosure [Line Items]
Research credits	7,626
Expires 2029-2038
Income Tax Disclosure [Line Items]
Federal losses carryovers	273,585
California loss carryovers	59,752
Expires 2029-2038 | Federal
Income Tax Disclosure [Line Items]
Research credits	5,736
No Expiration
Income Tax Disclosure [Line Items]
Federal losses carryovers	60,257
No Expiration | California
Income Tax Disclosure [Line Items]
Research credits	$ 10,220

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