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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2019 | Mar. 31, 2018
Operating activities |  |
Net loss | $ (18,792) | $ (13,885)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 729 | 413
Stock-based compensation | 2,878 | 2,315
Non-cash interest expense | 197 | 269
Changes in operating assets and liabilities: |  |
Accounts receivable | (5,004) | 1,926
Inventories | (2,286) | 1,224
Other assets | 2,165 | (1,475)
Accounts payable | 2,597 | (122)
Accrued liabilities and other non-current liabilities | (4,809) | (1,340)
Manufacturing and development obligations | (118) | 164
Deferred product revenue | 265 | 186
Net cash used in operating activities | (22,178) | (10,325)
Investing activities |  |
Capital expenditures | (3,315) | (52)
Purchases of investments | (1,000) | (56,941)
Proceeds from maturities and sale of investments | 17,500 | 12,250
Net cash provided by (used in) investing activities | 13,185 | (44,743)
Financing activities |  |
Net proceeds from equity incentives | 710 | 1,295
Net proceeds from public offering |  | 57,564
Proceeds from loans, net of discount | 39,433 |
Repayment of debt | (31,010) | (32)
Net cash provided by financing activities | 9,133 | 58,827
Net increase in cash, cash equivalents and restricted cash | 140 | 3,759
Cash, cash equivalents and restricted cash, beginning of period | 31,587 | 13,930
Cash, cash equivalents and restricted cash, end of period | $ 31,727 | $ 17,689

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