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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2019 | Sep. 30, 2018
Operating activities |  |
Net loss | $ (54,321) | $ (41,359)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 1,781 | 1,109
Stock-based compensation | 9,612 | 7,579
Non-cash lease expense | 1,224 |
Non-cash interest expense | 343 | 892
Loss on disposal of property and equipment | 14 | 5
Changes in operating assets and liabilities: |  |
Accounts receivable | (5,750) | 1,939
Inventories | (7,459) | 1,043
Other assets | 1,876 | (2,724)
Accounts payable | 3,005 | 3,020
Accrued liabilities and other non-current liabilities | (1,377) | 4,459
Manufacturing and development obligations | (6,288) | (187)
Deferred product revenue | 63 | 73
Net cash used in operating activities | (57,277) | (24,151)
Investing activities |  |
Capital expenditures | (8,460) | (624)
Purchases of investments | (34,756) | (80,453)
Proceeds from maturities and sale of investments | 62,000 | 30,002
Net cash provided by (used in) investing activities | 18,784 | (51,075)
Financing activities |  |
Net proceeds from equity incentives | 2,854 | 7,150
Net proceeds from public offering | 17,803 | 79,301
Net proceeds from revolving line of credit | 4,993 |
Proceeds from loans | 39,433 |
Repayment of debt | (31,080) | (99)
Net cash provided by financing activities | 34,003 | 86,352
Net (decrease) increase in cash, cash equivalents and restricted cash | (4,490) | 11,126
Cash, cash equivalents and restricted cash, beginning of period | 31,587 | 13,930
Cash, cash equivalents and restricted cash, end of period | $ 27,097 | $ 25,056

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