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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
Operating activities |  |  |
Net loss | $ (71,244) | $ (57,564) | $ (60,585)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 2,403 | 1,445 | 1,811
Stock-based compensation | 13,312 | 10,394 | 9,355
Non-cash operating lease cost | 1,580 |  |
Non-cash interest expense | 386 | 1,248 | 551
Loss on disposal of property and equipment | 15 | 5 |
Non-cash tax expense from realized gain on available-for-sale securities |  |  | 3,825
Gain on sale of investment in marketable equity securities |  |  | (3,466)
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (8,130) | 3,663 | (5,547)
Inventories | (6,043) | 806 | (2,092)
Other assets | 1,787 | (2,744) | 1,107
Accounts payable | 5,017 | 5,683 | 2,487
Accrued liabilities and other non-current liabilities | 1,295 | 6,046 | (626)
Manufacturing and development obligations | (6,288) | (266) | 680
Deferred product revenue | 72 | 38 | 265
Net cash used in operating activities | (65,838) | (31,246) | (52,235)
Investing activities |  |  |
Capital expenditures | (8,935) | (1,144) | (353)
Purchases of investments | (43,907) | (80,701) | (68,792)
Proceeds from maturities and sale of investments | 81,027 | 37,997 | 69,566
Net cash provided by (used in) investing activities | 28,185 | (43,848) | 421
Financing activities |  |  |
Net proceeds from equity incentives | 3,210 | 7,848 | 2,428
Net proceeds from public offering | 26,931 | 85,036 | 30,197
Net proceeds from revolving line of credit | 5,017 |  |
Proceeds from loans | 39,433 |  | 30,000
Repayment of debt | (31,104) | (133) | (19,625)
Net cash provided by financing activities | 43,487 | 92,751 | 43,000
Net increase (decrease) in cash, cash equivalents and restricted cash | 5,834 | 17,657 | (8,814)
Cash, cash equivalents and restricted cash, beginning of period | 31,587 | 13,930 | 22,744
Cash, cash equivalents and restricted cash, end of period | 37,421 | 31,587 | 13,930
Supplemental disclosure of cash flow information: |  |  |
Cash paid for interest | 3,077 | 2,728 | 2,034
Cash paid for income taxes | 229 | 254 | $ 160
Non-cash investing activities: |  |  |
Non-cash purchases of capital expenditures | $ 2,949 | $ 2,222 |

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