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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Operating activities |  |  |
Net loss | $ (59,857) | $ (71,244) | $ (57,564)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 3,109 | 2,403 | 1,445
Stock-based compensation | 18,029 | 13,312 | 10,394
Non-cash operating lease cost | 1,346 | 1,580 |
Changes in valuation of warrant investment | (422) |  |
Net loss on sale of available-for-sale securities | 234 |  | 1,248
Loss on disposal of property and equipment |  | 15 | 5
Impairment of long-lived assets | 274 |  |
Non-cash interest expense | 478 | 386 |
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (4,284) | (8,130) | 3,663
Inventories | (4,030) | (6,043) | 806
Other assets | (623) | 1,787 | (2,744)
Accounts payable | 2,236 | 5,017 | 5,683
Accrued liabilities and other non-current liabilities | 2,760 | 1,295 | 6,046
Manufacturing and development obligations |  | (6,288) | (266)
Deferred product revenue | 7 | 72 | 38
Net cash used in operating activities | (40,743) | (65,838) | (31,246)
Investing activities |  |  |
Capital expenditures | (1,615) | (8,935) | (1,144)
Purchases of investments | (98,793) | (43,907) | (80,701)
Proceeds from maturities and sale of investments | 50,850 | 81,027 | 37,997
Net cash (used in) provided by investing activities | (49,558) | 28,185 | (43,848)
Financing activities |  |  |
Net proceeds from equity incentives | 11,750 | 3,210 | 7,848
Net proceeds from public offerings | 76,534 | 26,931 | 85,036
Net proceeds from revolving line of credit | 3,499 | 5,017 |
Proceeds from loans |  | 39,433 |
Repayment of debt |  | (31,104) | (133)
Net cash provided by financing activities | 91,783 | 43,487 | 92,751
Net decrease in cash, cash equivalents and restricted cash | 1,482 | 5,834 | 17,657
Cash, cash equivalents and restricted cash, beginning of period | 37,421 | 31,587 | 13,930
Cash, cash equivalents and restricted cash, end of period | 38,903 | 37,421 | 31,587
Supplemental disclosure of cash flow information: |  |  |
Cash paid for interest | 3,269 | 3,077 | 2,728
Cash paid for income taxes | $ 265 | 229 | 254
Non-cash investing activities: |  |  |
Non-cash leasehold improvements |  | $ 2,949 | $ 2,222

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