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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2021
Mar. 31, 2020
Operating activities    
Net loss $ (17,457) $ (16,466)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 794 706
Stock-based compensation 5,333 3,754
Non-cash operating lease cost 361 300
Changes in valuation of warrant investment (220)  
Loss on sale of available-for-sale securities   267
Unrealized gain on investments (208)  
Non-cash interest expense 104 119
Changes in operating assets and liabilities:    
Accounts receivable 2,913 (1,283)
Inventories (1,036) (2,226)
Other assets (2,626) 1,119
Accounts payable (1,550) (2,308)
Accrued liabilities and other non-current liabilities (4,863) (4,356)
Deferred product revenue 479 572
Net cash used in operating activities (17,976) (19,802)
Investing activities    
Capital expenditures (193) (452)
Purchases of investments (1,915) (68,520)
Proceeds from maturities and sale of investments 23,500 18,787
Net cash provided by (used in) investing activities 21,392 (50,185)
Financing activities    
Net proceeds from equity incentives 1,218 1,193
Net (payments for) proceeds from public offerings (152) 67,695
Net proceeds (payments) on revolving line of credit 1,422 (204)
Proceeds from loans 15,000  
Net cash provided by financing activities 17,488 68,684
Net increase (decrease) in cash, cash equivalents and restricted cash 20,904 (1,303)
Cash, cash equivalents and restricted cash, beginning of period 38,903 37,421
Cash, cash equivalents and restricted cash, end of period $ 59,807 $ 36,118