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Significant Components of Deferred Tax Assets and Liabilities (Detail) - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 136,632 | $ 150,523
Research and development credit carryforwards | 29,242 | 29,411
Capitalized research and development | 27,916 | 8,406
Compensation related items | 12,014 | 11,951
Operating leases | 3,786 | 4,125
Other | 9,056 | 8,218
Total deferred tax assets | 218,646 | 212,634
Valuation allowance | (215,903) | (209,524)
Net deferred tax assets | 2,743 | 3,110
Deferred tax liabilities: |  |
Right-of-use assets | 2,610 | 2,895
Other | 194 | 313
Total deferred tax liabilities | $ 2,804 | $ 3,208

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