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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Operating activities |  |  |
Net loss | $ (42,825) | $ (54,376) | $ (59,857)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 2,984 | 3,148 | 3,109
Stock-based compensation | 24,456 | 23,571 | 18,029
Non-cash operating lease cost | 1,575 | 1,422 | 1,435
Impairment (unrealized gain) in private company investment | 2,183 | 239 | (422)
Net loss (gain) on sale of available-for-sale securities | 108 | (21) | 234
Unrealized gain on investments | (564) | (267) |
Impairment of long-lived assets |  |  | 274
Non-cash interest expense | 609 | 591 | 478
Foreign currency remeasurement loss (gain) | 1,911 | 511 | (887)
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (9,200) | (4,215) | (4,125)
Inventories | (1,768) | (19,610) | (4,030)
Prepaid and other assets | 1,168 | 2,738 | (597)
Accounts payable | (4,905) | 12,204 | 1,984
Accrued liabilities and other non-current liabilities | (1,263) | 47 | 2,557
Deferred product revenue | (84) | 96 | 7
Net cash used in operating activities | (25,615) | (33,922) | (41,811)
Investing activities |  |  |
Capital expenditures | (2,000) | (910) | (1,615)
Purchases of investments | (29,640) | (52,066) | (98,793)
Proceeds from maturities and sale of investments | 40,104 | 65,664 | 50,850
Net cash provided by (used in) investing activities | 8,464 | 12,688 | (49,558)
Financing activities |  |  |
Net proceeds from equity incentives | 4,084 | 9,370 | 11,750
Net (costs) proceeds from public offerings | (104) | 2,743 | 76,534
Net proceeds on revolving line of credit | 212 | 6,181 | 3,499
Proceeds from loans |  | 15,000 |
Contribution from noncontrolling interest |  | 1,000 |
Net cash provided by financing activities | 4,192 | 34,294 | 91,783
Effect of exchange rates on cash, cash equivalents, and restricted cash | (727) | (919) | 1,068
Net (decrease) increase in cash, cash equivalents and restricted cash | (13,686) | 12,141 | 1,482
Cash, cash equivalents and restricted cash, beginning of period | 51,044 | 38,903 | 37,421
Cash, cash equivalents and restricted cash, end of period | 37,358 | 51,044 | 38,903
Supplemental disclosure of cash flow information: |  |  |
Cash paid for interest | 5,100 | 4,181 | 3,269
Cash paid for income taxes | $ 270 | $ 278 | $ 265

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