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Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Income Statement [Abstract]
Revenue	$ 0	$ 0
Operating expenses:
Research and development	12,433	9,677
General and administrative	3,269	3,588
Total operating expenses	15,702	13,265
Loss from operations	(15,702)	(13,265)
Other income (expense):
Interest income	267	227
Interest expense	(458)	(73)
Foreign currency transaction gains (losses), net	(63)	100
Total other income (expense), net	(254)	254
Net loss	$ (15,956)	$ (13,011)
Net loss per share, basic and diluted	$ (0.58)	$ (0.48)
Weighted average common shares outstanding, basic and diluted	27,541,594	27,350,673
Comprehensive loss:
Net loss	$ (15,956)	$ (13,011)
Other comprehensive loss:
Unrealized gain on marketable securities	9	17
Total other comprehensive income (loss)	9	17
Total comprehensive loss	$ (15,947)	$ (12,994)

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Amount after tax of increase (decrease) in equity from transactions and other events and circumstances from net income and other comprehensive income, attributable to parent entity. Excludes changes in equity resulting from investments by owners and distributions to owners.

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