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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Cash flows from operating activities:    
Net loss $ (15,956) $ (13,011)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation expense 2,466 2,001
Non-cash interest expense   7
Depreciation expense 50 41
Unrealized foreign currency transaction losses (gains) 14 (21)
Premium on marketable securities (3) (210)
Amortization of premium on marketable securities (11) 64
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 507 (20)
Tax incentive receivable (581)  
Accounts payable 776 (662)
Accrued expenses (527) 132
Net cash used in operating activities (13,265) (11,679)
Cash flows from investing activities:    
Proceeds from sales and maturities of marketable securities 30,839 41,493
Purchases of marketable securities (12,880) (32,792)
Purchases of property and equipment (1) (10)
Net cash provided by investing activities 17,958 8,691
Cash flows from financing activities:    
Repayments of notes payable   (772)
Proceeds from exercise of common stock options and employee stock purchase plan 261 40
Net cash provided by (used in) financing activities 261 (732)
Net increase (decrease) in cash and cash equivalents 4,954 (3,720)
Cash and cash equivalents at beginning of period 40,777 32,352
Cash and cash equivalents at end of period 45,731 28,632
Supplemental disclosure of cash flow information:    
Cash paid for interest $ 198 $ 59