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Summary of Significant Accounting Policies - Summary of Common Stock Equivalents Outstanding (Detail) - shares
6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Total potentially dilutive shares 6,270,457 4,196,931
Options to Purchase Common Stock [Member]    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Total potentially dilutive shares 6,261,528 4,185,866
Unvested Restricted Common Stock [Member]    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Total potentially dilutive shares 8,929 11,065