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Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Income Statement [Abstract]
Revenue	$ 0	$ 0	$ 0	$ 0
Operating expenses:
Research and development	12,209	10,528	24,642	20,205
General and administrative	3,351	3,008	6,620	6,596
Total operating expenses	15,560	13,536	31,262	26,801
Loss from operations	(15,560)	(13,536)	(31,262)	(26,801)
Other income (expense):
Interest income	324	247	591	474
Interest expense	(466)	(53)	(924)	(126)
Foreign currency transaction (losses) gains, net	(73)	(5)	(136)	95
Total other (expense) income, net	(215)	189	(469)	443
Net loss	$ (15,775)	$ (13,347)	$ (31,731)	$ (26,358)
Net loss per share, basic and diluted	$ (0.57)	$ (0.49)	$ (1.15)	$ (0.96)
Weighted average common shares outstanding, basic and diluted	27,565,064	27,407,408	27,553,394	27,379,122
Comprehensive loss:
Net loss	$ (15,775)	$ (13,347)	$ (31,731)	$ (26,358)
Other comprehensive loss:
Unrealized gain on marketable securities	43	22	52	39
Total other comprehensive income	43	22	52	39
Total comprehensive loss	$ (15,732)	$ (13,325)	$ (31,679)	$ (26,319)

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