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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Cash flows from operating activities:    
Net loss $ (31,731) $ (26,358)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation expense 5,137 4,103
Non-cash interest expense   10
Depreciation expense 102 89
Unrealized foreign currency transaction losses (gains) 74 (21)
Premium on marketable securities, net (3) (224)
Amortization of (discount) premium on marketable securities (96) 145
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 638 (247)
Tax incentive receivable (961) (234)
Accounts payable (150) 1,875
Accrued expenses 413 (998)
Net cash used in operating activities (26,577) (21,860)
Cash flows from investing activities:    
Proceeds from sales and maturities of marketable securities 62,193 79,994
Purchases of marketable securities (35,871) (57,300)
Purchases of property and equipment (20) (16)
Net cash provided by investing activities 26,302 22,678
Cash flows from financing activities:    
Repayments of notes payable   (1,559)
Proceeds from exercise of common stock options and employee stock purchase plan 347 115
Payment of public offering costs (104)  
Net cash provided by (used in) financing activities 243 (1,444)
Net decrease in cash and cash equivalents (32) (626)
Cash and cash equivalents at beginning of period 40,777 32,352
Cash and cash equivalents at end of period 40,745 31,726
Supplemental disclosure of non-cash investing and financing activities:    
Property and equipment included in accounts payable 26  
Public offering costs included in accounts payable and accrued expenses 196  
Supplemental disclosure of cash flow information:    
Cash paid for interest $ 502 $ 103