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Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Income Statement [Abstract]
Revenue	$ 0	$ 0	$ 0	$ 0
Operating expenses:
Research and development	5,260	11,830	23,463	36,472
General and administrative	3,627	3,339	10,891	9,959
Restructuring charges	4,019		4,019
Total operating expenses	12,906	15,169	38,373	46,431
Loss from operations	(12,906)	(15,169)	(38,373)	(46,431)
Other income (expense):
Interest income	451	623	1,654	1,214
Interest expense	(426)	(475)	(1,404)	(1,399)
Foreign currency transaction losses, net	(33)	(46)	(32)	(182)
Total other income (expense), net	(8)	102	218	(367)
Net loss	$ (12,914)	$ (15,067)	$ (38,155)	$ (46,798)
Net loss per share, basic and diluted	$ (0.35)	$ (0.41)	$ (1.02)	$ (1.53)
Weighted average common shares outstanding, basic and diluted	37,369,829	36,619,575	37,337,081	30,608,664
Comprehensive loss:
Net loss	$ (12,914)	$ (15,067)	$ (38,155)	$ (46,798)
Other comprehensive income:
Unrealized gain (loss) on marketable debt securities	11	(22)	74	30
Total other comprehensive income (loss)	11	(22)	74	30
Total comprehensive loss	$ (12,903)	$ (15,089)	$ (38,081)	$ (46,768)

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