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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2019
Sep. 30, 2018
Cash flows from operating activities:    
Net loss $ (38,155) $ (46,798)
Adjustments to reconcile net loss to net cash used in operating activities    
Stock-based compensation expense 4,555 7,337
Depreciation expense 185 209
Impairment of assets 80  
Loss on disposal of property and equipment 6  
Unrealized foreign currency transaction losses 13 45
Premium on marketable securities, net (39) (3)
Amortization of discount on marketable securities (706) (345)
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 526 (465)
Tax incentive receivable 1,288 (344)
Accounts payable (556) (397)
Accrued restructuring costs 3,619  
Accrued expenses and other (1,830) 1,108
Other assets 37  
Net cash used in operating activities (30,977) (39,653)
Cash flows from investing activities:    
Proceeds from sales and maturities of marketable securities 101,920 84,938
Purchases of marketable securities (71,035) (105,976)
Purchases of property and equipment (479) (96)
Proceeds from sales of property and equipment 3  
Payments for leasehold improvements on right-of-use assets (586)  
Net cash provided by (used in) investing activities 29,823 (21,134)
Cash flows from financing activities:    
Proceeds from public offering, net of issuance costs   64,560
Repayments of notes payable (3,636)  
Proceeds from exercise of common stock options and employee stock purchase plan 135 591
Net cash (used in) provided by financing activities (3,501) 65,151
Net (decrease) increase in cash, cash equivalents and restricted cash (4,655) 4,364
Cash, cash equivalents and restricted cash at beginning of period 49,331 40,777
Cash, cash equivalents and restricted cash at end of period 44,676 45,141
Supplemental disclosure of non-cash investing and financing activities:    
Property and equipment included in accounts payable and accrued expenses 285 4
Supplemental disclosure of cash flow information:    
Cash paid for interest $ 969 $ 819