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Commitments and Contingencies - Additional Information (Detail) $ in Thousands |  |  |  |  |  |  | 3 Months Ended |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Aug. 09, 2021 | Oct. 27, 2020 USD ($) | Aug. 04, 2020 | May 28, 2020 USD ($) ft² | Aug. 08, 2019 | Nov. 05, 2018 | Mar. 31, 2022 USD ($) | Mar. 31, 2021 USD ($) | Dec. 31, 2021 | Nov. 30, 2016 USD ($)
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |
Milestone expenses |  |  |  |  |  |  | $ 0 |  |  |
Milestone payments due |  |  |  |  |  |  | $ 0 |  |  |
Weighted average remaining lease term in years |  |  |  |  |  |  | 7 years 4 months 24 days |  | 7 years 7 months 6 days |
Weighted average discount rate |  |  |  |  |  |  | 11.00% |  | 11.00% |
Lease expenses |  |  |  |  |  |  | $ 100 | $ 100 |  |
Pennsylvania [Member] | Office [Member] |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |
Operating lease term |  |  |  |  | 3 years 6 months |  |  |  |  |
Lease extension period |  |  |  |  | 3 years |  |  |  |  |
Lease term commencement date |  |  |  |  | Feb. 15, 2020 |  |  |  |  |
Pennsylvania [Member] | Office and Lab [Member] |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |
Lease extension period |  |  |  |  |  | 2 years |  |  |  |
Lease term commencement date |  |  |  |  |  | Jan. 01, 2019 |  |  |  |
Lease term expiration date | Dec. 31, 2022 |  | Dec. 31, 2021 |  |  | Dec. 31, 2020 |  |  |  |
Massachusetts [Member] | Office [Member] |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |
Area of office space | ft² |  |  |  | 17,705 |  |  |  |  |  |
Lease term expiration date |  |  |  | Oct. 30, 2029 |  |  |  |  |  |
Massachusetts [Member] | Office [Member] | Letter of Credit |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |
Letter of credit |  |  |  | $ 1,300 |  |  |  |  |  |
Massachusetts [Member] | Office Sublease [Member] |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |
Lease term commencement date |  | Dec. 04, 2020 |  |  |  |  |  |  |  |
Lease term expiration date |  | Oct. 30, 2029 |  |  |  |  |  |  |  |
Massachusetts [Member] | First Sublease Year [Member] | Office Sublease [Member] |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |
Annual base rent |  | $ 800 |  |  |  |  |  |  |  |
Massachusetts [Member] | First Sublease Year [Member] | Office Sublease [Member] | Letter of Credit |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |
Lease security deposits letters of credit |  | 800 |  |  |  |  |  |  |  |
Massachusetts [Member] | Final Sublease Year [Member] | Office Sublease [Member] |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |
Annual base rent |  | 1,000 |  |  |  |  |  |  |  |
Massachusetts [Member] | Sixth Sublease Year | Office Sublease [Member] | Letter of Credit |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |
Lease security deposits letters of credit |  | $ 400 |  |  |  |  |  |  |  |
WFUHS [Member] |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |
License agreement consideration deduction percentage |  |  |  |  |  |  |  |  |  | 60.00%
WFUHS [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |
Milestone payments |  |  |  |  |  |  |  |  |  | $ 2,600
IU [Member] |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |
License agreement consideration deduction percentage |  |  |  |  |  |  |  |  |  | 20.00%
IU [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |
Milestone payments |  |  |  |  |  |  |  |  |  | $ 2,600
Annual royalty pay obligation |  |  |  |  |  |  |  |  |  | $ 100

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