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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Cash flows from operating activities:    
Net loss $ (8,943) $ (12,088)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation expense 1,635 1,180
Depreciation expense 82 73
Amortization of premium on marketable securities   (5)
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets (208) 625
Accounts payable 657 564
Accrued expenses (752) (1,232)
Right-of-use assets 136 131
Operating lease liabilities (141) (123)
Other assets 1 (331)
Net cash used in operating activities: (7,533) (11,206)
Cash flows from investing activities:    
Purchase of marketable debt securities   (1,749)
Maturities and sales of marketable debt securities   7,000
Net cash provided by investing activities   5,251
Cash flows from financing activities:    
Net increase in cash, cash equivalents and restricted cash (7,533) (5,955)
Cash, cash equivalents and restricted cash at beginning of period 71,436 69,487
Cash, cash equivalents and restricted cash at end of period 63,903 63,532
Supplemental disclosure of non-cash investing and financing activities:    
Property and equipment included in accounts payable and accrued expenses $ 100 $ 31