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Income Taxes - Schedule of Net Deferred Tax Assets (Detail) - USD ($) $ in Thousands | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
--- | --- | --- | ---
Deferred tax assets: |  |  |
Capitalized R&D - acquired in merger with Zafgen | $ 66,678 | $ 66,941 |
Capitalized R&D - Section 174 Costs post 2021 | 9,411 | 5,019 |
Stock based compensation | 3,490 | 2,709 |
Net operating loss carryforwards | 45,195 | 42,204 |
Tax credit carryforwards | 16,319 | 13,284 |
Other temporary differences | 21 | 20 |
Accruals & reserves | 19 | 19 |
Fixed assets & intangibles | 107 | 81 |
Operating lease liability | 1,298 | 1,355 |
Total deferred tax assets | 142,538 | 131,632 |
Deferred tax liabilities: |  |  |
Operating right of use asset | (768) | (801) |
Total deferred tax liabilities | (768) | (801) |
Less: Valuation allowance | $ (141,770) | $ (130,831) | $ (124,016)

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