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Income Taxes - Additional Information (Detail) - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2023 | Dec. 31, 2022
Income Taxes Disclosure [Line Items] |  |
Income tax benefit | $ 0 | $ 0
Net capitalized R&D deferred tax assets | 66,678,000 | 66,941,000
Net deferred tax assets before the valuation allowance | 141,800,000 | 130,800,000
Unrecognized tax benefits | 0 | $ 0
Zafgen [Member] |  |
Income Taxes Disclosure [Line Items] |  |
Net operating loss carryforwards | 33,500,000 |
Net capitalized R&D deferred tax assets | $ 66,900,000 |
Net capitalized R&D deferred tax assets realization description | is subject to the built-in loss rules under Section 382 and may not be realized if the underlying asset associated with the R&D is disposed within five years of the Merger, or May 28, 2025 |
Net operating loss carryforwards, change in ownership, annual utilization limit | $ 35,000 |
Earliest Tax Year [Member] |  |
Income Taxes Disclosure [Line Items] |  |
Open tax year | 2019 |
Domestic Tax Authority [Member] |  |
Income Taxes Disclosure [Line Items] |  |
Net operating loss carryforwards | $ 179,000,000 |
Net operating loss carryforwards, beginning of expiration period | 2026 |
Domestic Tax Authority [Member] | No Expiration [Member] |  |
Income Taxes Disclosure [Line Items] |  |
Net operating loss carryforwards | $ 140,300,000 |
Operating loss carryforwards, minimum percentage of taxable income in tax period | 80.00% |
Operating loss carryforwards, description | carryforwards are limited to 80% of the taxable income in any one tax period. |
Foreign Tax Authority [Member] |  |
Income Taxes Disclosure [Line Items] |  |
Net operating loss carryforwards | $ 1,200,000 |
State and Local Jurisdiction [Member] |  |
Income Taxes Disclosure [Line Items] |  |
Net operating loss carryforwards | $ 148,100,000 |
Net operating loss carryforwards, beginning of expiration period | 2030 |
Federal and State [Member] |  |
Income Taxes Disclosure [Line Items] |  |
Tax credit carryforward | $ 16,300,000 |
Research and development tax credit carry forwards, beginning of expiration period | 2039 |
IRC Section 174 [Member] | Performed in US [Member] |  |
Income Taxes Disclosure [Line Items] |  |
Capitalized research and development amortization period | 5 years |
IRC Section 174 [Member] | Performed outside US [Member] |  |
Income Taxes Disclosure [Line Items] |  |
Capitalized research and development amortization period | 15 years |

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