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Income Taxes - Additional Information (Detail) - USD ($)
 12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Income Taxes Disclosure [Line Items]    
Income tax benefit $ 0 $ 0
Net capitalized R&D deferred tax assets 66,678,000 66,941,000
Net deferred tax assets before the valuation allowance 141,800,000 130,800,000
Unrecognized tax benefits 0 $ 0
Zafgen [Member]    
Income Taxes Disclosure [Line Items]    
Net operating loss carryforwards 33,500,000  
Net capitalized R&D deferred tax assets $ 66,900,000  
Net capitalized R&D deferred tax assets realization description is subject to the built-in loss rules under Section 382 and may not be realized if the underlying asset associated with the R&D is disposed within five years of the Merger, or May 28, 2025  
Net operating loss carryforwards, change in ownership, annual utilization limit $ 35,000  
Earliest Tax Year [Member]    
Income Taxes Disclosure [Line Items]    
Open tax year 2019  
Domestic Tax Authority [Member]    
Income Taxes Disclosure [Line Items]    
Net operating loss carryforwards $ 179,000,000  
Net operating loss carryforwards, beginning of expiration period 2026  
Domestic Tax Authority [Member] | No Expiration [Member]    
Income Taxes Disclosure [Line Items]    
Net operating loss carryforwards $ 140,300,000  
Operating loss carryforwards, minimum percentage of taxable income in tax period 80.00%  
Operating loss carryforwards, description carryforwards are limited to 80% of the taxable income in any one tax period.  
Foreign Tax Authority [Member]    
Income Taxes Disclosure [Line Items]    
Net operating loss carryforwards $ 1,200,000  
State and Local Jurisdiction [Member]    
Income Taxes Disclosure [Line Items]    
Net operating loss carryforwards $ 148,100,000  
Net operating loss carryforwards, beginning of expiration period 2030  
Federal and State [Member]    
Income Taxes Disclosure [Line Items]    
Tax credit carryforward $ 16,300,000  
Research and development tax credit carry forwards, beginning of expiration period 2039  
IRC Section 174 [Member] | Performed in US [Member]    
Income Taxes Disclosure [Line Items]    
Capitalized research and development amortization period 5 years  
IRC Section 174 [Member] | Performed outside US [Member]    
Income Taxes Disclosure [Line Items]    
Capitalized research and development amortization period 15 years