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Description of Business and Basis of Presentation - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands	1 Months Ended	12 Months Ended
	Feb. 29, 2024	Dec. 31, 2024	Dec. 31, 2023
Net loss		$ 80,604	$ 36,949
Cash flow used in operations		70,760	33,459
Accumulated deficit		(269,158)	$ (188,554)
Cash, cash equivalents and marketable securities		$ 183,500
Common Stock [Member]
Issuance of common stock	19,736,842	19,736,842
Share price per share	$ 8.74
Proceeds net of issuance costs	$ 161,800
Buccal Cells [Member] | Beginning of Study [Member]
Percentage of increasing from mean level		15.00%
Buccal Cells [Member] | End of Study [Member]
Percentage of increasing from mean level		30.00%
Skin Cells [Member] | Beginning of Study [Member]
Percentage of increasing from mean level		16.00%
Skin Cells [Member] | End of Study [Member]
Percentage of increasing from mean level		72.00%

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