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Commitments and Contingencies - Additional Information (Detail) $ in Thousands										1 Months Ended	12 Months Ended
	Oct. 16, 2023	Mar. 09, 2023 ft²	Aug. 09, 2021	Oct. 27, 2020 USD ($)	Aug. 04, 2020	May 28, 2020 USD ($) ft²	Dec. 11, 2019 USD ($)	Aug. 08, 2019 ft²	Nov. 05, 2018	Oct. 31, 2022 USD ($)	Dec. 31, 2024 USD ($)	Dec. 31, 2023 USD ($)	Oct. 31, 2024 USD ($)	May 10, 2024 USD ($)	Oct. 01, 2023 USD ($)	Sep. 01, 2023 USD ($)	Nov. 30, 2016 USD ($)
Other Commitments [Line Items]
Operating lease right-of-use assets											$ 2,838	$ 3,078
Operating lease liabilities											$ 4,057	$ 4,709
Weighted average remaining lease term in years											4 years 6 months	5 years 6 months
Weighted average discount rate											11.00%	11.00%
Lease expenses											$ 500	$ 400
Pennsylvania [Member] | Office [Member]
Other Commitments [Line Items]
Operating lease term								3 years 6 months
Lease extension period								3 years
Lease term commencement date		Sep. 01, 2023						Feb. 15, 2020
Operating lease right-of-use assets																$ 500
Operating lease liabilities																$ 500
Area of office space | ft²		4,642						4,642
Lease term expiration date								Aug. 31, 2023
Pennsylvania [Member] | Office and Lab [Member]
Other Commitments [Line Items]
Lease extension period									2 years
Lease term commencement date									Jan. 01, 2019
Lease term expiration date			Dec. 31, 2022		Dec. 31, 2021				Dec. 31, 2020
Pennsylvania [Member] | Additional Office [Member]
Other Commitments [Line Items]
Lease term commencement date		Oct. 01, 2023
Operating lease right-of-use assets															$ 300
Operating lease liabilities															$ 300
Area of office space | ft²		3,462
Pennsylvania [Member] | Lab Space [Member]
Other Commitments [Line Items]
Operating lease term	4 years
Lease term commencement date	May 10, 2024
Operating lease right-of-use assets														$ 500
Operating lease liabilities														$ 500
Massachusetts [Member] | Office [Member]
Other Commitments [Line Items]
Area of office space | ft²						17,705
Lease term expiration date						Oct. 30, 2029
Massachusetts [Member] | Office Sublease [Member]
Other Commitments [Line Items]
Lease term commencement date				Dec. 04, 2020
Lease term expiration date				Oct. 30, 2029
Massachusetts [Member] | Letter of Credit [Member] | Office [Member]
Other Commitments [Line Items]
Letter of credit						$ 1,300							$ 600
Massachusetts [Member] | First Sublease Year [Member] | Office Sublease [Member]
Other Commitments [Line Items]
Annual base rent				$ 800
Massachusetts [Member] | First Sublease Year [Member] | Letter of Credit [Member] | Office Sublease [Member]
Other Commitments [Line Items]
Lease security deposits letters of credit				800
Massachusetts [Member] | Final Sublease Year [Member] | Office Sublease [Member]
Other Commitments [Line Items]
Annual base rent				1,000
Massachusetts [Member] | Sixth Sublease Year [Member] | Letter of Credit [Member] | Office Sublease [Member]
Other Commitments [Line Items]
Lease security deposits letters of credit				$ 400
WFUHS [Member]
Other Commitments [Line Items]
License agreement consideration deduction percentage																	60.00%
WFUHS [Member] | Maximum [Member]
Other Commitments [Line Items]
Milestone payments																	$ 2,600
IU [Member]
Other Commitments [Line Items]
License agreement consideration deduction percentage																	20.00%
IU [Member] | Maximum [Member]
Other Commitments [Line Items]
Milestone payments																	$ 2,600
Annual royalty pay obligation																	$ 100
WFUHS and IU [Member] | Research and Development Expenses [Member]
Other Commitments [Line Items]
Milestone expenses										$ 300
WFUHS and IU [Member] | Maximum [Member]
Other Commitments [Line Items]
Payment for license agreements							$ 100

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