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Condensed Consolidated Statement of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
CASH FLOWS FROM OPERATING ACTIVITIES    
Net loss $ (166,513) $ (165,615)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 9,059 2,842
Stock-based compensation expense 41,023 20,290
Change in fair value of success payment liabilities 19,343 3,793
Change in fair value of warrants 199 (1,295)
Non-cash lease expense 1,486 4,694
Non-cash expense in connection with asset acquisition 0 3,529
Net amortization or accretion on marketable securities 1,434 67
Loss on property and equipment disposals 496 0
Changes in operating assets and liabilities:    
Prepaid expenses and other assets (6,811) (596)
Accounts payable (8) (616)
Accrued liabilities and other current liabilities 10,792 4,209
Deferred revenue (7,697) (5,444)
Other non-current liabilities 4,121 0
Net cash used in operating activities (93,076) (134,142)
CASH FLOWS FROM INVESTING ACTIVITIES    
Purchases of property and equipment (55,236) (26,600)
Sales of property and equipment 40
Purchases of marketable securities (539,541) (723,487)
Sales and maturities of marketable securities 547,066 480,631
Purchases of other investments (36,447)
Net cash used in investing activities (47,671) (305,903)
CASH FLOWS FROM FINANCING ACTIVITIES    
Proceeds from initial public offering, net of issuance costs 391,802
Proceeds from issuance of convertible preferred stock, net of issuance costs 492,467
Proceeds from exercise of stock options 2,043 35
Payments for the repurchase of common stock (11,806)
Payments for the repurchase of preferred stock (4,244)
Net cash provided by financing activities 393,845 476,452
Net increase in cash, cash equivalents and restricted cash 253,098 36,407
Cash, cash equivalents and restricted cash at beginning of period 140,872 98,472
Cash, cash equivalents and restricted cash at end of period 393,970 134,879
Represented by:    
Cash and cash equivalents 393,504 134,413
Restricted cash 466 466
SUPPLEMENTAL CASH FLOW INFORMATION    
Conversion of convertible preferred stock to common stock upon closing of initial public offering 1,010,968
Purchases of property and equipment included in accounts payable and accrued liabilities 5,432 18,439
Operating lease right-of-use assets obtained in exchange for lease obligations 30,475
Remeasurement of operating lease right of use asset for lease modification 4,078 2,963
Cash received for amounts related to tenant improvement allowances 11,063 2,705
Cash paid for amounts included in the measurement of lease liabilities $ 5,658 $ 3,628