<SEC-DOCUMENT>0001012975-25-000768.txt : 20251114
<SEC-HEADER>0001012975-25-000768.hdr.sgml : 20251114
<ACCEPTANCE-DATETIME>20251114163004
ACCESSION NUMBER:		0001012975-25-000768
CONFORMED SUBMISSION TYPE:	SCHEDULE 13G/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20251114
DATE AS OF CHANGE:		20251114

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Lyell Immunopharma, Inc.
		CENTRAL INDEX KEY:			0001806952
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				833006753
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-93402
		FILM NUMBER:		251487015

	BUSINESS ADDRESS:	
		STREET 1:		201 HASKINS WAY
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
		BUSINESS PHONE:		650 695-0677

	MAIL ADDRESS:	
		STREET 1:		201 HASKINS WAY
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ARCH Venture Fund IX, L.P.
		CENTRAL INDEX KEY:			0001666306
		ORGANIZATION NAME:           	
		EIN:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		8755 W. HIGGINS ROAD, SUITE 1025
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60631
		BUSINESS PHONE:		773-380-6600

	MAIL ADDRESS:	
		STREET 1:		8755 W. HIGGINS ROAD, SUITE 1025
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60631
</SEC-HEADER>
<DOCUMENT>
<TYPE>SCHEDULE 13G/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
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      <eventDateRequiresFilingThisStatement>09/30/2025</eventDateRequiresFilingThisStatement>
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        <issuerName>Lyell Immunopharma, Inc.</issuerName>
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      <reportingPersonName>ARCH Venture Partners IX, L.P.</reportingPersonName>
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      <reportingPersonName>ARCH Venture Partners IX Overage, L.P.</reportingPersonName>
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      <reportingPersonName>ARCH Venture Partners IX, LLC</reportingPersonName>
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      <reportingPersonName>ARCH Venture Partners XIII, L.P.</reportingPersonName>
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        <soleVotingPower>0</soleVotingPower>
        <sharedVotingPower>2759072</sharedVotingPower>
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        <sharedDispositivePower>2759072</sharedDispositivePower>
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      <reportingPersonName>ARCH Venture Partners XIII, LLC</reportingPersonName>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
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      <classPercent>13.0</classPercent>
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      <reportingPersonName>Keith Crandell</reportingPersonName>
      <citizenshipOrOrganization>X1</citizenshipOrOrganization>
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        <sharedVotingPower>2759072</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>2759072</sharedDispositivePower>
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      <classPercent>13.0</classPercent>
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      <reportingPersonName>Clinton Bybee</reportingPersonName>
      <citizenshipOrOrganization>X1</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
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        <sharedVotingPower>1820634</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>1820634</sharedDispositivePower>
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      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>1820634</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
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      <classPercent>8.6</classPercent>
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      <reportingPersonName>Robert Nelsen</reportingPersonName>
      <citizenshipOrOrganization>X1</citizenshipOrOrganization>
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        <sharedVotingPower>2759072</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>2759072</sharedDispositivePower>
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      <reportingPersonName>Kristina Burow</reportingPersonName>
      <citizenshipOrOrganization>X1</citizenshipOrOrganization>
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        <sharedDispositivePower>2759072</sharedDispositivePower>
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      <reportingPersonName>Steven Gillis</reportingPersonName>
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      <reportingPersonName>Paul Berns</reportingPersonName>
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    <items>
      <item1>
        <issuerName>Lyell Immunopharma, Inc.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>201 Haskins Way, South San Francisco, CA 94080</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>ARCH Venture Fund IX, L.P. ("AVF IX"); ARCH Venture Partners IX, L.P. ("AVP IX LP"); ARCH Venture Partners IX, LLC ("AVP IX LLC"); ARCH Venture Fund IX Overage, L.P. ("AVF IX Overage"); ARCH Venture Partners IX Overage, L.P. ("AVF IX Overage GP"); ARCH Venture Fund XIII, L.P. ("AVF XIII"); ARCH Venture Partners XIII, L.P. ("AVP XIII LP"); ARCH Venture Partners XIII, LLC ("AVP XIII LLC") (collectively, the "Reporting Entities" and individually, each a "Reporting Entity"); and Keith Crandell ("Crandell"), Robert Nelsen ("Nelsen") and Clinton Bybee ("Bybee") (collectively, the "IX Managing Directors" and individually, each a "IX Managing Director"), Steven Gillis ("Gillis") and Kristina Burow ("Burow"), along with Nelsen and Crandell, collectively the "IX Investment Committee" and individually "IX Committee Members"; and Paul Berns ("Berns"), along with Nelsen, Crandell, Gillis, and Burow, collectively the "XIII Investment Committee" and individually "XIII Committee Members". The Reporting Entities, IX Managing Directors, IX Committee Members, and XIII Committee Members collectively are referred to as the "Reporting Persons".</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>8755 W. Higgins Avenue, Suite 1025, Chicago, IL 60631</principalBusinessOfficeOrResidenceAddress>
        <citizenship>Each of AVF IX, AVF IX LP, AVF IX Overage, AVF IX Overage GP, AVF XIII and AVF XIII LP are limited partnerships organized under the laws of the State of Delaware. AVP IX LLC and AVP XIII LLC are each a limited liability company organized under the laws of the State of Delaware.  Each Managing Director is a US citizen.</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>AVF IX is the record owner of 910,317 shares of Common Stock (the "AVF IX Shares") as of September 30, 2025. AVP IX LP, as the sole general partner of AVF IX, may be deemed to beneficially own the AVF IX Shares.

AVF IX Overage is the record owner of 910,317 shares of Common Stock (the "AVF IX Overage Shares") as of September 30, 2025. AVF IX Overage GP, as the sole general partner of AVF IX Overage, may be deemed to beneficially own the AVF IX Overage Shares, combined with AVF IX Shares (the "IX Record Shares").

AVF XIII is the record owner of 938,438 shares of Common Stock (the "XIII Record Shares") as of September 30, 2025. AVP XIII LP, as the sole general partner of AVF XIII, may be deemed to beneficially own the XIII Record Shares.

AVP IX LLC, as the sole general partner of AVP IX LP and AVF IX Overage GP, may be deemed to beneficially own the IX Record Shares. As managing directors and investment committee members of AVP IX LLC, each IX Managing Director and IX Committee Members may also be deemed to share the power to direct the disposition and vote of the IX Record Shares.

AVP XIII LLC, as the sole general partner of AVP XIII LP, may be deemed to beneficially own the XIII Record Shares. As investment committee members of AVP XIII LLC, XIII Committee Members may also be deemed to share the power to direct the disposition and vote of the XIII Record Shares.

The information required by Item 4(b) is incorporated by reference to Row 11 of the cover pages hereto. The percentages set forth on the cover sheet for each Reporting Person is based upon 21,218,217 shares of common stock outstanding as of November 10, 2025, as reported on the Issuer's Quarterly Report on Form 10-Q as filed with the Securities and Exchange Commission on November 12, 2025.</amountBeneficiallyOwned>
        <classPercent>See row 11 of the cover pages.</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>See row 5 of the cover pages.</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>See row 6 of the cover pages.</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>See row 7 of the cover pages.</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>See row 8 of the cover pages.</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>Y</notApplicableFlag>
      </item10>
    </items>
    <exhibitInfo>Exhibit 99.1 Joint Filing Agreement</exhibitInfo>
    <signatureInformation>
      <reportingPersonName>ARCH Venture Fund IX, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ ARCH Venture Partners IX, L.P.</signature>
        <title>its General Partner</title>
        <date>11/14/2025</date>
      </signatureDetails>
      <signatureDetails>
        <signature>ARCH Venture Partners IX, LLC</signature>
        <title>its General Partner</title>
        <date>11/14/2025</date>
      </signatureDetails>
      <signatureDetails>
        <signature>/s/ Mark McDonnell</signature>
        <title>Mark McDonnell as Attorney-in-Fact for Keith Crandell, Managing Director</title>
        <date>11/14/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>ARCH Venture Fund IX Overage, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ ARCH Venture Partners IX Overage, L.P.</signature>
        <title>its General Partner</title>
        <date>11/14/2025</date>
      </signatureDetails>
      <signatureDetails>
        <signature>/s/ ARCH Venture Partners IX, LLC</signature>
        <title>its General Partner</title>
        <date>11/14/2025</date>
      </signatureDetails>
      <signatureDetails>
        <signature>/s/ Mark McDonnell</signature>
        <title>Mark McDonnell as Attorney-in-Fact for Keith Crandell, Managing Director</title>
        <date>11/14/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>ARCH Venture Fund XIII, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ ARCH Venture Partners XIII, L.P.</signature>
        <title>its General Partner</title>
        <date>11/14/2025</date>
      </signatureDetails>
      <signatureDetails>
        <signature>/s/ ARCH Venture Partners XII, LLC</signature>
        <title>its General Partner</title>
        <date>11/14/2025</date>
      </signatureDetails>
      <signatureDetails>
        <signature>/s/ Mark McDonnell</signature>
        <title>Mark McDonnell as Attorney-in-Fact for Keith Crandell, Managing Director</title>
        <date>11/14/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>ARCH Venture Partners IX, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ ARCH Venture Partners IX, LLC</signature>
        <title>its General Partner</title>
        <date>11/14/2025</date>
      </signatureDetails>
      <signatureDetails>
        <signature>/s/ Mark McDonnell</signature>
        <title>Mark McDonnell as Attorney-in-Fact for Keith Crandell, Managing Director</title>
        <date>11/14/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>ARCH Venture Partners IX Overage, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ ARCH Venture Partners IX, LLC</signature>
        <title>its General Partner</title>
        <date>11/14/2025</date>
      </signatureDetails>
      <signatureDetails>
        <signature>/s/ Mark McDonnell</signature>
        <title>Mark McDonnell as Attorney-in-Fact for Keith Crandell, Managing Director</title>
        <date>11/14/2025</date>
      </signatureDetails>
      <signatureDetails>
        <signature>/s/ Mark McDonnell</signature>
        <title>Mark McDonnell as Attorney-in-Fact for Robert Nelsen</title>
        <date>11/14/2025</date>
      </signatureDetails>
      <signatureDetails>
        <signature>/s/ Mark McDonnell</signature>
        <title>Mark McDonnell as Attorney-in-Fact for Clinton Bybee</title>
        <date>11/14/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>ARCH Venture Partners IX, LLC</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Mark McDonnell</signature>
        <title>Mark McDonnell as Attorney-in-Fact for Keith Crandell, Managing Director</title>
        <date>11/14/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>ARCH Venture Partners XIII, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ ARCH Venture Partners XIII, LLC</signature>
        <title>its General Partner</title>
        <date>11/14/2025</date>
      </signatureDetails>
      <signatureDetails>
        <signature>/s/ Mark McDonnell</signature>
        <title>Mark McDonnell as Attorney-in-Fact for Keith Crandell, Managing Director</title>
        <date>11/14/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>ARCH Venture Partners XIII, LLC</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Mark McDonnell</signature>
        <title>Mark McDonnell as Attorney-in-Fact for Keith Crandell, Managing Director</title>
        <date>11/14/2025</date>
      </signatureDetails>
      <signatureDetails>
        <signature>/s/ Mark McDonnell</signature>
        <title>Mark McDonnell as Attorney-in-Fact for Robert Nelsen</title>
        <date>11/14/2025</date>
      </signatureDetails>
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        <signature>/s/ Mark McDonnell</signature>
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        <signature>/s/ Mark McDonnell</signature>
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      <reportingPersonName>Keith Crandell</reportingPersonName>
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      <reportingPersonName>Clinton Bybee</reportingPersonName>
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      <reportingPersonName>Robert Nelsen</reportingPersonName>
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    <signatureComments>* This Schedule 13G was executed by Mark McDonnell pursuant to a Power of Attorney filed as Exhibit 24 to the Form 3 relating to the beneficial ownership of shares of Gossamer Bio, Inc. by the Reporting Persons filed with the Securities Exchange Commission on February 7, 2019 and incorporated herein in its entirety by reference.</signatureComments>
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<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>ormp-ex99_1.htm
<DESCRIPTION>EX-99.1
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<!-- DFIN ActiveDisclosure (SM) HTML Document - http://www.dfinsolutions.com/ --><!-- Creation Date :2025-11-14T15:16:56.2503+00:00 --><!-- Copyright (c) 2025 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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  <div style="padding-top:0.5in;z-index:2;min-height:1in;position:relative;box-sizing:border-box;"><p style="font-size:10pt;margin-top:0;font-family:Times New Roman;margin-bottom:0;text-align:left;margin-left:0;margin-right:0;"><font style="white-space:pre-wrap;font-size:12pt;font-family:Times New Roman;font-kerning:none;min-width:fit-content;">&#160;</font></p></div>
  <div class="main-content-container" style="z-index:5;position:relative;"><p style="font-size:10pt;margin-top:0;font-family:Times New Roman;margin-bottom:0;text-align:right;"><font style="color:#000000;white-space:pre-wrap;font-weight:bold;font-size:11pt;font-family:Times New Roman;font-kerning:none;min-width:fit-content;">Exhibit 99.1</font></p><p style="font-size:10pt;margin-top:0;font-family:Times New Roman;margin-bottom:0;text-align:center;"><font style="white-space:pre-wrap;font-size:11pt;font-family:Times New Roman;font-kerning:none;min-width:fit-content;">&#160;</font></p><p style="font-size:10pt;margin-top:0;font-family:Times New Roman;margin-bottom:0;text-align:center;"><font style="color:#000000;white-space:pre-wrap;font-weight:bold;font-size:11pt;font-family:Times New Roman;font-kerning:none;min-width:fit-content;">JOINT FILING AGREEMENT<br></font><font style="color:#000000;white-space:pre-wrap;font-weight:bold;font-size:11pt;font-family:Times New Roman;font-kerning:none;min-width:fit-content;">&#160;</font></p><p style="text-indent:6.944%;font-size:10pt;margin-top:0;font-family:Times New Roman;margin-bottom:12pt;margin-right:4%;text-align:left;"><font style="color:#000000;white-space:pre-wrap;font-size:11pt;font-family:Times New Roman;font-kerning:none;min-width:fit-content;">Pursuant to Rule 13d-1-(k)(1) under the Securities Exchange Act of 1934, the undersigned hereby agree that only one statement containing the information required by Schedule 13G need be filed with respect to the ownership by each of the undersigned of shares of stock of Lyell Immunopharma, Inc.</font></p><p style="text-indent:6.667%;font-size:10pt;margin-top:0;font-family:Times New Roman;margin-bottom:0;text-align:left;"><font style="color:#000000;white-space:pre-wrap;font-size:11pt;font-family:Times New Roman;font-kerning:none;min-width:fit-content;">This Agreement may be executed in any number of counterparts, each of which shall be deemed an original.</font></p><p style="font-size:10pt;margin-top:0;font-family:Times New Roman;margin-bottom:0;text-align:left;"><font style="white-space:pre-wrap;font-size:12pt;font-family:Times New Roman;font-kerning:none;min-width:fit-content;">&#160;</font></p><p style="text-indent:-7.143%;padding-left:6.667%;font-size:10pt;margin-top:0;font-family:Times New Roman;margin-bottom:0;text-align:left;"><font style="color:#000000;white-space:pre-wrap;font-size:11pt;font-family:Times New Roman;font-kerning:none;min-width:fit-content;">Dated: November 14, 2025</font></p><p style="text-indent:-7.143%;padding-left:6.667%;font-size:10pt;margin-top:0;font-family:Times New Roman;margin-bottom:0;text-align:left;"><font style="white-space:pre-wrap;font-size:11pt;font-family:Times New Roman;font-kerning:none;min-width:fit-content;">&#160;</font></p><p style="text-indent:-7.143%;padding-left:6.667%;font-size:10pt;margin-top:0;font-family:Times New Roman;margin-bottom:0;text-align:right;"><font 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  <hr style="margin-inline-start:auto;margin-inline-end:auto;page-break-after:always;">
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  <div class="main-content-container" style="z-index:5;position:relative;"><p style="font-size:10pt;margin-top:0;font-family:Times New Roman;margin-bottom:0;text-align:left;"><font style="white-space:pre-wrap;font-size:11pt;font-family:Times New Roman;font-kerning:none;min-width:fit-content;">&#160;</font></p><p style="font-size:10pt;margin-top:0;font-family:Times New Roman;margin-bottom:0;text-align:left;"><font style="white-space:pre-wrap;font-size:11pt;font-family:Times New Roman;font-kerning:none;min-width:fit-content;">&#160;</font></p><p style="font-size:10pt;margin-top:0;font-family:Times New Roman;margin-bottom:0;text-align:left;"><font style="color:#000000;white-space:pre-wrap;font-size:11pt;font-family:Times New Roman;font-kerning:none;min-width:fit-content;">ARCH VENTURE PARTNERS IX, L.P.</font></p><p style="font-size:10pt;margin-top:0;font-family:Times New Roman;margin-bottom:0;text-align:left;"><font style="white-space:pre-wrap;font-size:11pt;font-family:Times New 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solid;font-size:11pt;font-family:Times New Roman;font-kerning:none;min-width:fit-content;">		*		</font></p><p style="font-size:10pt;margin-top:0;font-family:Times New Roman;margin-bottom:0;text-align:left;"><font style="color:#000000;white-space:pre-wrap;font-size:11pt;font-family:Times New Roman;font-kerning:none;min-width:fit-content;">	Keith Crandell</font></p><p style="text-indent:6.667%;font-size:10pt;margin-top:0;font-family:Times New Roman;margin-bottom:0;text-align:left;"><font style="color:#000000;white-space:pre-wrap;font-size:11pt;font-family:Times New Roman;font-kerning:none;min-width:fit-content;">Managing Director</font></p><p style="font-size:10pt;margin-top:0;font-family:Times New Roman;margin-bottom:0;text-align:left;"><font style="white-space:pre-wrap;font-size:11pt;font-family:Times New Roman;font-kerning:none;min-width:fit-content;">&#160;</font></p><p style="font-size:10pt;margin-top:0;font-family:Times New Roman;margin-bottom:0;text-align:left;"><font 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