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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2025
Mar. 31, 2024
Operating activities:    
Net loss $ (67,992) $ (53,721)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation 9,324 7,373
Non-cash operating lease expense 877 791
Depreciation and amortization 157 158
Net accretion of investments in marketable securities (1,289) (1,147)
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 966 7,351
Accounts payable (2,255) 1,155
Accrued liabilities 1,679 (4,113)
Operating lease liabilities (915) (802)
Net cash used in operating activities (59,448) (42,955)
Investing activities:    
Purchases of marketable securities (44,385) (185,804)
Cash paid for acquisition of assets 0 (775)
Proceeds from maturities of marketable securities 88,545 36,578
Net cash provided by (used in) investing activities 44,160 (150,001)
Financing activities:    
Proceeds from exercise of stock options 0 1,845
Net cash provided by financing activities 0 1,845
Net change in cash and cash equivalents and restricted cash (15,288) (191,111)
Cash and cash equivalents and restricted cash at beginning of year 143,361 375,251
Cash and cash equivalents and restricted cash at end of period 128,073 184,140
Components of cash and restricted cash:    
Cash and cash equivalents 126,860 182,927
Restricted Cash 1,213 1,213
Total cash and cash equivalents and restricted cash $ 128,073 $ 184,140