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CONSOLIDATED STATEMENTS OF OPERATIONS (USD $)
In Thousands, except Share data, unless otherwise specified
 12 Months Ended
Dec. 31, 2011
Dec. 31, 2010
Dec. 31, 2009
Revenue $ 4,524 $ 2,105 $ 1,444
Operating expenses:      
Research and development 23,718 23,465 16,929
General and administrative 8,216 8,746 5,273
Total operating expenses 31,934 32,211 22,202
Loss from operations (27,410) (30,106) (20,758)
Investment income 51 167 214
Interest expense (1,884) (1,535) (2,202)
Loss on extinguishment of debt   (296)  
Other income, net 697 2,519 1,657
Net loss $ (28,546) $ (29,251) $ (21,089)
Basic and diluted net loss per share $ (1.29) $ (1.37) $ (2.92)
Weighted-average shares used to compute basic and diluted net loss per share 22,212,351 21,420,883 7,218,915