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CONSOLIDATED STATEMENTS OF CONVERTIBLE PREFERRED STOCK AND SHAREHOLDERS' EQUITY (DEFICIT) (Parenthetical) (USD $)
In Thousands, except Per Share data, unless otherwise specified
 12 Months Ended
Dec. 31, 2011
Dec. 31, 2010
Dec. 31, 2009
Issuance of stock, price per share   $ 8.30  
Research and Development Funding Arrangement
      
Issuance of stock, price per share     $ 15.11
Initial Public Offering
      
Issuance of stock, price per share     $ 10
Issuance of stock, offering costs     $ 6,388
Minimum
      
Issuance of stock, price per share $ 0.52 $ 0.52 $ 0.98
Maximum
      
Issuance of stock, price per share $ 2.45 $ 6.05 $ 2.45