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Stock-Based Compensation (Tables) | 6 Months Ended
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Jun. 30, 2013
Schedule of Weighted Average Assumptions for Employee Stock Option Grants | The fair value of each employee option grant was estimated on the date of grant using the Black-Scholes option- pricing model with the following assumptions during the periods ended:
| Three Months Ended June 30, |  | Six Months Ended June 30,
| 2013 |  | 2012 |  | 2013 |  | 2012
Estimated weighted-average fair value | $ | 3.57 |  |  | $ | 7.09 |  |  | $ | 3.57 |  |  | $ | 3.28 |
Weighted-average assumptions |  |  |  |  |  |  |
Expected volatility | 82 | % |  | 86 | % |  | 82 | % |  | 89 | %
Expected term, in years | 5.5 |  |  | 5.5 |  |  | 5.5 |  |  | 5.7 |
Risk-free interest rate | 1.02 | % |  | 0.78 | % |  | 1.02 | % |  | 1.05 | %
Expected dividend yield | — | % |  | — | % |  | — | % |  | — | %
Stock-Based Compensation Expense | Stock-based compensation expense includes amortization of stock options granted to employees and non-employees’ and has been reported in our consolidated statements of operations as follows:
| Three Months Ended June 30, |  | Six Months Ended June 30,
| 2013 |  | 2012 |  | 2013 |  | 2012
| (In thousands) |  | (In thousands)
Research and development | $ | 566 |  |  | $ | 285 |  |  | $ | 1,147 |  |  | $ | 853 |
Selling, general and administrative | 494 |  |  | 284 |  |  | 1,006 |  |  | 847 |
Total | $ | 1,060 |  |  | $ | 569 |  |  | $ | 2,153 |  |  | $ | 1,700 |
Stock Option Activity and Related Information | Stock option activity and related information is as follows:
| Options Outstanding |  | Weighted- Average Exercise Price per Share |  | Remaining Contractual Life (in years) |  | Aggregate Intrinsic Value (In thousands)
Balance at December 31, 2012 | 5,390,582 |  |  | $ | 5.18 |  |  |  |  |
Granted | 25,000 |  |  | 5.30 |  |  |  |  |
Exercised | (32,284 | ) |  | 1.31 |  |  |  |  |
Forfeited | (74,437 | ) |  | 7.45 |  |  |  |  |
Balance at June 30, 2013 | 5,308,861 |  |  | $ | 5.18 |  |  | 6.76 |  | $ | 7,650 |
Vested and expected to vest at June 30, 2013 | 5,142,695 |  |  | $ | 5.09 |  |  | 6.70 |  | $ | 7,604 |
Exercisable at June 30, 2013 | 3,540,828 |  |  | $ | 3.87 |  |  | 5.75 |  | $ | 7,191 |

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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 123R -Paragraph 64 -Subparagraph b -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB TOPIC 14.F) -URI http://asc.fasb.org/extlink&oid=6793087&loc=d3e301413-122809 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 123R -Paragraph A240 -Subparagraph g(1) -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Staff Accounting Bulletin (SAB) -Number Topic 14 -Section F Reference 6: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of share-based compensation plans that may be presented in a single table for outstanding, vested and expected to vest, and exercisable awards. The information that may be disclosed in this table may include, but is not limited to, number of shares, weighted average exercise price, weighted average remaining contractual life, and aggregate intrinsic value. + References No definition available. + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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