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Commitments and Contingencies (Detail) (USD $) | 1 Months Ended | 3 Months Ended | 6 Months Ended |  |  |  | 1 Months Ended |  |  | 1 Months Ended |  | 6 Months Ended |  | 1 Months Ended |
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Nov. 30, 2012 | Oct. 31, 2012 | Nov. 30, 2010 warrant | Jun. 30, 2013 | Jun. 30, 2012 | Jun. 30, 2013 Leases | Jun. 30, 2012 | Mar. 29, 2007 | Jun. 30, 2013 Stanley Medical Research Institute Maximum | Feb. 28, 2011 Individual Maximum | Jan. 31, 2013 Daiichi Sankyo Company Limited | Jun. 30, 2013 Daiichi Sankyo Company Limited Scenario 1 | Jan. 31, 2013 Daiichi Sankyo Company Limited Maximum | Apr. 30, 2010 Helion Biotech ApS | Apr. 30, 2010 Helion Biotech ApS Maximum | Jun. 30, 2013 Vulcan and Life Sciences Discovery Fund Authority | Oct. 31, 2010 Vulcan and Life Sciences Discovery Fund Authority | Oct. 31, 2010 Vulcan Incorporated | Oct. 31, 2010 Vulcan Incorporated Warrant 1 | Oct. 31, 2010 Vulcan Incorporated Warrant 2 | Oct. 31, 2010 Vulcan Incorporated Warrant 3 | Oct. 31, 2010 Life Sciences Discovery Fund Authority
Commitments and Contingencies Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential future payments |  |  |  |  |  |  |  |  | $ 12,800,000 | $ 3,800,000 |  | $ 23,500,000 | $ 33,500,000 |  | $ 6,900,000 |  |  |  |  |  |  |
Research and development expense |  |  |  | 9,564,000 | 7,558,000 | 16,691,000 | 14,804,000 |  |  |  | 50,000 |  |  | 500,000 |  |  |  |  |  |  |  |
Potential future net proceeds |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,500,000,000 |  |  |  |  |
Eligible expenses and expenditures deducted for computation of net proceeds |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 25,000,000 |  |  |  |  |  |
Number of warrants issued |  |  | 3 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants, exercisable, amount of shares |  |  |  |  |  |  |  | 197,478 |  |  |  |  |  |  |  |  |  |  | 133,333 | 133,333 | 133,333 |
Warrants, term |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5 years | 5 years | 5 years |
Warrants, exercise price per share |  |  |  |  |  |  |  | 12.25 |  |  |  |  |  |  |  |  |  |  | 20 | 30 | 40 |
Amount payable under agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 25,000,000 |  |  |  |
Term of agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 35 years |  |  |  |
Amount payable under agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 25,000,000
Number of Options to extend the lease term |  |  |  |  |  | 2 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Options to extend the lease term, number of options |  |  |  |  |  | 5 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Remaining aggregate rent payable |  |  |  | 61,700,000 |  | 61,700,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net lease incentives |  |  |  | 4,400,000 |  | 4,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Prior grants received, under review |  |  |  |  |  | 1,100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Settlement agreement, one-time payment |  | 3,940,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Defense costs paid by insurer associated with lawsuit |  |  |  |  |  | 2,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Litigation recovery | 3,950,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Settlement agreement, related employment taxes incurred |  | $ 13,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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- Definition The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 985 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6501960&loc=d3e128462-111756 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 2 -Paragraph 12, 13 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 141 -Paragraph 51 -Subparagraph g -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 86 -Paragraph 11, 12 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. + Details
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