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Revenue (Detail) (USD $)
 6 Months Ended 3 Months Ended 6 Months Ended 1 Months Ended 3 Months Ended 6 Months Ended 3 Months Ended
Jun. 30, 2013
Jun. 30, 2012
Jun. 30, 2013
Small Business Innovative Research
Jun. 30, 2012
Small Business Innovative Research
Jun. 30, 2013
Small Business Innovative Research
Jun. 30, 2012
Small Business Innovative Research
Oct. 31, 2010
Vulcan Incorporated
Mar. 31, 2013
Vulcan Incorporated
Jun. 30, 2012
Vulcan Incorporated
Jun. 30, 2013
Vulcan Incorporated
Jun. 30, 2012
Vulcan Incorporated
Mar. 31, 2012
Life Sciences Discovery Fund Authority
Oct. 31, 2010
Life Sciences Discovery Fund Authority
Revenue [Line Items]                          
Grant revenue recognized     $ 140,000 $ 329,000 $ 265,000 $ 489,000           $ 624,000  
Remaining available amount under grant     1,600,000   1,600,000                
Grants received             20,000,000            
Cost reduction to intellectual property assets             10,800,000            
Fair value of warrants issued             994,000            
Deferred revenue             8,200,000            
Maximum contractual amount from grant                         5,000,000
Reductions to deferred revenue               970,000 1,300,000 970,000 2,000,000    
Deferred Revenue, Revenue Recognized                 1,200,000   1,900,000    
Reduction of equipment cost basis due to assets purchased with grant funding $ 0 $ 59,000                 $ 60,000