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Commitments and Contingencies (Detail) (USD $)	3 Months Ended		9 Months Ended
	Sep. 30, 2014	Sep. 30, 2013	Sep. 30, 2014 Leases	Sep. 30, 2013
Commitments and Contingencies Disclosure [Line Items]
Number of Options to extend the lease term			2
Options to extend the lease term, number of options			5 years
Remaining aggregate rent payable	$ 59,400,000		$ 59,400,000
Research and development expense	11,772,000	9,420,000	36,196,000	26,111,000
InVentiv [Member]
Commitments and Contingencies Disclosure [Line Items]
Recorded Unconditional Purchase Obligation, Due in Remainder of Fiscal Year	300,000		300,000
Unrecorded Unconditional Purchase Obligation, Change of Amount as Result of Variable Components	630,000		630,000
DSM [Member]
Commitments and Contingencies Disclosure [Line Items]
Unrecorded Unconditional Purchase Obligation	519,000		519,000
Helion Biotech ApS
Commitments and Contingencies Disclosure [Line Items]
Research and development expense			200,000
Selling, General and Administrative Expenses
Commitments and Contingencies Disclosure [Line Items]
Government Grants Under Review				$ 900,000

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Grants received by entity between 2004 and 2007 under administrative review.

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Lease Extension Period

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Amount of required minimum rental payments for leases having an initial or remaining non-cancelable letter-terms in excess of one year.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 840

-SubTopic 20

-Section 50

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Amount of the recorded unconditional purchase obligation maturing in the remainder of the fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date.

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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Amount of the unrecorded obligation to transfer funds in the future for fixed or minimum amounts or quantities of goods or services at fixed or minimum prices (for example, as in take-or-pay contracts or throughput contracts).

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Amount of change that payments under a contractual obligation might vary as facts and circumstances change.

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