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CONSOLIDATED STATEMENTS OF CASH FLOWS (USD $)
 9 Months Ended
Sep. 30, 2014
Sep. 30, 2013
Operating activities:    
Net loss $ (52,960,000) $ (37,951,000)
Adjustments to reconcile net loss to net cash used in operating activities:    
Gain on disposal of assets (9,000) 0
Depreciation and amortization 246,000 222,000
Stock-based compensation expense 5,083,000 4,364,000
Non-cash interest expense 532,000 371,000
Warrant modification expense 863,000 41,000
Changes in operating assets and liabilities:    
Grant and other receivables (2,000) 1,053,000
Prepaid expenses and other current and noncurrent assets (842,000) 31,000
Accounts payable and accrued expenses 3,949,000 453,000
Deferred revenue 0 (970,000)
Deferred rent 787,000 2,987,000
Net cash used in operating activities (42,353,000) (29,399,000)
Investing activities:    
Purchases and sales of property and equipment, net (12,000) (137,000)
Purchases of investments (58,847,000) (22,963,000)
Proceeds from the sale and maturities of investments 50,534,000 35,945,000
Net cash (used in) provided by investing activities (8,325,000) 12,845,000
Financing activities:    
Proceeds from issuance of common stock, net of offering costs 37,754,000 16,120,000
Proceeds from Issuance of Long-term Debt 12,699,000 0
Payments on notes payable (1,464,000) 0
Proceeds from Stock Options and Warrants Exercised 1,055,000  
Proceeds from Stock Options Exercised   64,000
Net cash provided by financing activities 50,044,000 16,184,000
Net decrease in cash and cash equivalents (634,000) (370,000)
Cash and cash equivalents at beginning of period 1,384,000 1,520,000
Cash and cash equivalents at end of period 750,000 1,150,000
Supplemental cash flow information    
Cash paid for interest 1,931,000 1,243,000
Small Business Innovative Research
    
Supplemental cash flow information    
Reduction of equipment cost basis purchased with grant funding $ 40,000 $ 0