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Net Loss Per Share (Tables)
6 Months Ended
Jun. 30, 2016
Earnings Per Share [Abstract]  
Calculation of Historical Outstanding Dilutive Securities Not Included in Diluted Loss per Share
Potentially dilutive securities excluded from the diluted loss per share calculation are as follows:
 
June 30,
 
2016
 
2015
Outstanding options to purchase common stock
9,501,818

 
8,427,501

Warrants and pre-funded warrants to purchase common stock
100,602

 
1,149,249

Total
9,602,420

 
9,576,750