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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2016
Jun. 30, 2015
Jun. 30, 2016
Jun. 30, 2015
Product sales, net $ 10,004 $ 3,125 $ 17,250 $ 3,363
Grant revenue 0 62 173 212
Revenue 10,004 3,187 17,423 3,575
Costs and expenses        
Cost of product sales 327 365 654 376
Research and development 10,231 10,900 25,665 20,218
Selling, general and administrative 10,375 7,889 21,485 16,878
Total costs and expenses 20,933 19,154 47,804 37,472
Loss from operations (10,929) (15,967) (30,381) (33,897)
Interest expense (1,857) (937) (3,232) (1,894)
Other income (expense), net 174 224 462 442
Net loss (12,612) (16,680) (33,151) (35,349)
Comprehensive loss $ (12,612) $ (16,680) $ (33,151) $ (35,349)
Basic and diluted net loss per share (USD per share) $ (0.32) $ (0.44) $ (0.86) $ (0.95)
Weighted-average shares used to compute basic and diluted net loss per share (shares) 39,178,547 37,846,832 38,747,816 37,165,196