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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2016
Jun. 30, 2015
Operating activities:    
Net loss $ (33,151) $ (35,349)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 122 107
Stock-based compensation expense 7,031 4,898
Non-cash interest expense 684 442
Changes in operating assets and liabilities:    
Receivables (2,289) (2,679)
Inventory (1,308) (65)
Prepaid expenses and other assets (242) (228)
Accounts payable and accrued expenses (268) (1,229)
Deferred rent (2) 82
Net cash used in operating activities (29,423) (34,021)
Investing activities:    
Purchases and sales of property and equipment (34) (114)
Purchases of investments (20,625) (79,403)
Proceeds from the sale and maturities of investments 30,875 37,050
Net cash provided by (used in) investing activities 10,216 (42,467)
Financing activities:    
Proceeds from issuance of common stock and pre-funded warrants, net 724 79,076
Proceeds from borrowings under notes payable, net 19,864 0
Payments on notes payable (34) (2,342)
Proceeds upon exercise of stock options and warrants 1,877 1,961
Net cash provided by financing activities 22,431 78,695
Net increase in cash and cash equivalents 3,224 2,207
Cash and cash equivalents at beginning of period 1,365 354
Cash and cash equivalents at end of period 4,589 2,561
Supplemental cash flow information    
Cash paid for interest 2,005 1,471
Issuance of warrants in connection with the Amendment to the Loan Agreement 758 0
Property acquired under capital lease 388 0
Prepaid expenses not yet paid $ 1,035 $ 68