Net Loss Per Share

6 Months Ended

Jun. 30, 2016

Basic net loss per share is calculated by dividing the net loss by the weighted-average number of common shares outstanding for the period. Diluted net loss per share is computed by dividing the net loss by the weighted-average number of common shares and dilutive common share equivalents outstanding for the period, determined using the treasury-stock method.

The basic and diluted net loss per share amounts for the three and six months ended June 30, 2016 and 2015 were computed based on the shares of common stock outstanding during the respective periods. Potentially dilutive securities excluded from the diluted loss per share calculation are as follows:



	June 30,
	2016	2015
Outstanding options to purchase common stock	9,501,818	8,427,501
Warrants and pre-funded warrants to purchase common stock	100,602	1,149,249
Total	9,602,420	9,576,750