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Shareholders' Deficit- Equity Table (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2019 | Jun. 30, 2019 | Mar. 31, 2019 | Sep. 30, 2018 | Jun. 30, 2018 | Mar. 31, 2018 | Sep. 30, 2019 | Sep. 30, 2018
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Balance | $ (130,274) | $ (121,019) | $ (100,156) | $ (56,298) | $ (29,215) | $ (2,814) | $ (100,156) | $ (2,814)
Warrants issued |  |  |  |  | 1,424 |  |  |
Exercise of stock options | 3,326 | 1,600 | 108 | 3,844 | 2,190 | 687 |  |
Stock-based compensation expense | 3,496 | 3,598 | 3,374 | 2,929 | 3,000 | 2,966 |  |
Net loss | (16,463) | (14,453) | (24,345) | (39,472) | (33,697) | (30,054) | (55,261) | (103,223)
Balance | (139,915) | (130,274) | (121,019) | (88,997) | (56,298) | (29,215) | (139,915) | (88,997)
Common Stock [Member] |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Balance | 492 | 490 | 490 | 485 | 483 | 482 | 490 | 482
Exercise of stock options | 3 | 2 |  | 5 | 2 | 1 |  |
Balance | 495 | 492 | 490 | 490 | 485 | 483 | 495 | 490
Additional Paid-in Capital [Member] |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Balance | 558,157 | 552,961 | 549,479 | 530,336 | 523,724 | 520,072 | 549,479 | 520,072
Warrants issued |  |  |  |  | 1,424 |  |  |
Exercise of stock options | 3,323 | 1,598 | 108 | 3,839 | 2,188 | 686 |  |
Stock-based compensation expense | 3,496 | 3,598 | 3,374 | 2,929 | 3,000 | 2,966 |  |
Balance | 564,976 | 558,157 | 552,961 | 537,104 | 530,336 | 523,724 | 564,976 | 537,104
Retained Earnings [Member] |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Balance | (688,923) | (674,470) | (650,125) | (587,119) | (553,422) | (523,368) | (650,125) | (523,368)
Net loss | (16,463) | (14,453) | (24,345) | (39,472) | (33,697) | (30,054) |  |
Balance | $ (705,386) | $ (688,923) | $ (674,470) | $ (626,591) | $ (587,119) | $ (553,422) | $ (705,386) | $ (626,591)

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