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Stock-Based Compensation (Tables)

9 Months Ended

Sep. 30, 2019

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Stock-Based Compensation Expense

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Three Months Ended

Nine Months Ended

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September 30,

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September 30,

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2019

2018

2019

2018

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(In thousands)

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(In thousands)

Research and development

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$

1,558

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$

1,334

​

$

4,698

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$

3,720

Selling, general and administrative

​

1,938

​

1,595

​

5,770

​

5,176

Total

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$

3,496

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$

2,929

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$

10,468

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$

8,896

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Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions

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Three Months Ended

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Nine Months Ended

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September 30,

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September 30,

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2019

2018

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2019

2018

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Estimated weighted-average fair value

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$

11.81

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$

16.30

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$

9.91

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$

10.22

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Weighted-average assumptions:

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Expected volatility

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79

%

78

%

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81

%

77

%

Expected term, in years

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6.1

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6.1

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6.0

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6.0

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Risk-free interest rate

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2.10

%

2.77

%

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2.44

%

2.66

%

Expected dividend yield

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—

%

—

%

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—

%

—

%

Stock Option Activity and Related Information

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​	​	​	​	​	​	​	​	​	​	​
​		​		Weighted-			​		​	​
​	​	​	​	Average		​	​	​	Aggregate
​	​	​	​	Exercise		​	Remaining	​	Intrinsic
​	​	Options	​	Price per		​	Contractual Life	​	Value
​	​	Outstanding	​	Share		​	(In years)	​	(In thousands)
Balance at December 31, 2018		10,313,138	​	$	11.22				​
Granted		1,956,205	​		14.17				​
Exercised		(513,790)	​		9.80				​
Forfeited		(260,831)	​		16.07				​
Balance at September 30, 2019		11,494,722	​	$	11.67		6.25	​	$	56,610
Vested and expected to vest at September 30, 2019		11,126,906	​	$	11.59		6.17	​	$	55,668
Exercisable at September 30, 2019		8,117,842	​	$	10.68		5.20	​	$	47,725

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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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