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Shareholders' Deficit- Equity Table (Details) - USD ($) $ in Thousands	3 Months Ended						9 Months Ended
	Sep. 30, 2019	Jun. 30, 2019	Mar. 31, 2019	Sep. 30, 2018	Jun. 30, 2018	Mar. 31, 2018	Sep. 30, 2019	Sep. 30, 2018
Class of Stock [Line Items]
Balance	$ (130,274)	$ (121,019)	$ (100,156)	$ (56,298)	$ (29,215)	$ (2,814)	$ (100,156)	$ (2,814)
Warrants issued					1,424
Exercise of stock options	3,326	1,600	108	3,844	2,190	687
Stock-based compensation expense	3,496	3,598	3,374	2,929	3,000	2,966
Net loss	(16,463)	(14,453)	(24,345)	(39,472)	(33,697)	(30,054)	(55,261)	(103,223)
Balance	(139,915)	(130,274)	(121,019)	(88,997)	(56,298)	(29,215)	(139,915)	(88,997)
Common Stock [Member]
Class of Stock [Line Items]
Balance	492	490	490	485	483	482	490	482
Exercise of stock options	3	2		5	2	1
Balance	495	492	490	490	485	483	495	490
Additional Paid-in Capital [Member]
Class of Stock [Line Items]
Balance	558,157	552,961	549,479	530,336	523,724	520,072	549,479	520,072
Warrants issued					1,424
Exercise of stock options	3,323	1,598	108	3,839	2,188	686
Stock-based compensation expense	3,496	3,598	3,374	2,929	3,000	2,966
Balance	564,976	558,157	552,961	537,104	530,336	523,724	564,976	537,104
Retained Earnings [Member]
Class of Stock [Line Items]
Balance	(688,923)	(674,470)	(650,125)	(587,119)	(553,422)	(523,368)	(650,125)	(523,368)
Net loss	(16,463)	(14,453)	(24,345)	(39,472)	(33,697)	(30,054)
Balance	$ (705,386)	$ (688,923)	$ (674,470)	$ (626,591)	$ (587,119)	$ (553,422)	$ (705,386)	$ (626,591)

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