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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Income Statement [Abstract]
Product sales, net	$ 29,856	$ 4,608	$ 78,389	$ 7,852
Costs and expenses:
Cost of product sales	278	36	464	355
Research and development	23,746	26,862	69,108	64,414
Selling, general and administrative	16,933	13,152	48,493	36,830
Total costs and expenses	40,957	40,050	118,065	101,599
Loss from operations	(11,101)	(35,442)	(39,676)	(93,747)
Interest expense	(5,715)	(4,602)	(16,846)	(11,104)
Other income	353	572	1,261	1,628
Net loss	(16,463)	(39,472)	(55,261)	(103,223)
Comprehensive loss	$ (16,463)	$ (39,472)	$ (55,261)	$ (103,223)
Basic and diluted net loss per share (USD per share)	$ (0.33)	$ (0.81)	$ (1.12)	$ (2.13)
Weighted-average shares used to compute basic and diluted net loss per share ( in shares)	49,373,156	48,647,416	49,157,055	48,437,870

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