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Income Taxes - Significant Components of Deferred Tax Assets (Details) - USD ($) $ in Thousands | Dec. 31, 2020 | Dec. 31, 2019
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 149,993 | $ 126,794
Research and development tax credits | 56,103 | 40,654
Stock-based compensation | 10,586 | 9,959
Lease liability | 8,646 | 7,908
Disallowed interest expense | 11,859 | 8,122
Other | 7,411 | 6,433
Total deferred tax assets | 244,598 | 199,870
Deferred tax liabilities: |  |
Property and equipment | (113) |
Equity component of Convertible Notes | (18,302) | (11,082)
Right of use assets | (6,197) | (6,480)
Total deferred tax liabilities | 24,612 | 17,562
Net deferred tax assets before valuation allowance | 219,986 | 182,308
Less valuation allowance | (219,986) | (182,308)
Net deferred tax assets | $ 0 | $ 0

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