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Stock-Based Compensation (Tables)

12 Months Ended

Dec. 31, 2020

Stock-Based Compensation.

Schedule of equity plan

Vesting schedules for our equity plans generally are as follows:

​	​	​
Grant Type		Vesting Schedule
Employee initial grants		25% at one-year anniversary, 1/48 monthly thereafter
Employee recurring grants		1/48 monthly
Board member initial grants		33+% per year for 3 years
Board member recurring grants		100% after one year
Non-employee consultant grants		1/12 monthly
Non-employee consultant grants		1/48 monthly

Stock-Based Compensation Expense

​

​	​	​	​	​	​	​	​	​
​	​
​	Year Ended December 31,
​	2020			2019			2018
​	(In thousands)
Research and development	$	6,331	​	$	6,095	​	$	4,961
Selling, general and administrative		8,594	​		7,690	​		6,752
Total	$	14,925	​	$	13,785	​	$	11,713

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions

​

​	​	​	​	​	​	​	​	​	​
​	Year Ended December 31,
​	2020		​	2019		​	2018		​
Estimated weighted-average fair value	$	8.19	​	$	9.93	​	$	10.32	​
Weighted-average assumptions:		​	​			​			​
Expected volatility		77	%		80	%		78	%
Expected life, in years		6.0	​		6.0	​		6.0	​
Risk-free interest rate		1.06	%		2.41	%		2.68	%
Expected dividend yield		—	%		—	%		—	%

Schedule of Stock Option Activity

​

​	​	​	​	​	​	​	​	​	​	​
​		​		Weighted-			​		​	​
​	​	​	​	Average		​	​	​	Aggregate
​	​	​	​	Exercise		​	Remaining	​	Intrinsic
​	​	Options	​	Price per		​	Contractual Life	​	Value
​	​	Outstanding	​	Share		​	(In years)	​	(In thousands)
Balance at December 31, 2019		11,207,931	​	$	11.72				​
Granted		2,237,535	​		12.29				​
Exercised		(556,421)	​		9.03				​
Canceled		(950,517)	​		12.14				​
Balance at December 31, 2020		11,938,528	​	$	11.92		5.8	​	$	32,384
Vested and expected to vest at December 31, 2020		11,584,202	​	$	11.88		5.8	​	$	31,880
Exercisable at December 31, 2020		8,805,571	​	$	11.48		4.9	​	$	27,844

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