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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Revenue:      
Product sales, net $ 73,813 $ 111,805 $ 29,868
Costs and expenses:      
Cost of product sales 902 865 512
Research and development 110,817 109,696 89,860
Selling, general and administrative 72,695 64,626 51,718
Total costs and expenses 184,414 175,187 142,090
Loss from operations (110,601) (63,382) (112,222)
Loss on early extinguishment of debt (13,374)   (12,993)
Interest expense (26,751) (22,657) (16,252)
Other income 654 1,553 1,781
Loss before income tax benefit (150,072) (84,486) (139,686)
Income tax benefit 12,011 0 12,929
Net loss (138,061) (84,486) (126,757)
Comprehensive loss $ (138,061) $ (84,486) $ (126,757)
Basic and diluted net loss per share (USD per share) $ (2.41) $ (1.71) $ (2.61)
Weighted-average shares used to compute basic and diluted net loss per share ( in shares) 57,176,743 49,523,444 48,582,636
Revenue, Product and Service [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Cost, Product and Service [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember