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Stock-Based Compensation (Tables)

6 Months Ended

Jun. 30, 2021

Stock-Based Compensation.

Stock-Based Compensation Expense

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Three Months Ended

Six Months Ended

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June 30,

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June 30,

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2021

2020

2021

2020

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(In thousands)

Research and development

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$

1,410

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$

1,631

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$

2,890

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$

3,078

Selling, general and administrative

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1,707

​

2,191

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3,498

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4,220

Total

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$

3,117

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$

3,822

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$

6,388

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$

7,298

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Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions

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​	​	​	​	​	​	​	​	​	​
​		Three Months Ended			​	​	Six Months Ended
​	​	June 30, 2021			​	​	June 30, 2021
Estimated weighted-average fair value	​	$	11.29	​	​	​	$	12.79	​
Weighted-average assumptions:	​		​	​	​	​		​	​
Expected volatility	​		81	%	​	​		81	%
Expected life, in years	​		6.1	​	​	​		6.1	​
Risk-free interest rate	​		0.98	%	​	​		0.89	%
Expected dividend yield	​		—	%	​	​		—	%

Schedule of Stock Option Activity

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​	​	​	​	​	​	​	​	​	​	​
​		​		Weighted-			​		​	​
​	​	​	​	Average		​	​	​	Aggregate
​	​	​	​	Exercise		​	Remaining	​	Intrinsic
​	​	Options	​	Price per		​	Contractual Life	​	Value
​	​	Outstanding	​	Share		​	(In years)	​	(In thousands)
Balance at December 31, 2020		11,938,528	​	$	11.92				​
Granted		307,450	​		18.53				​
Exercised		(794,808)	​		9.40				​
Forfeited		(135,617)	​		15.42				​
Balance at June 30, 2021		11,315,553	​	$	12.24		5.7	​	$	33,730
Vested and expected to vest at June 30, 2021		11,019,841	​	$	12.20		5.6	​	$	33,217
Exercisable at June 30, 2021		8,719,802	​	$	11.82		4.9	​	$	29,075

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